Tsfm Gene Summary [Rat]
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to be located in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsfm |
| Official Name | Ts translation elongation factor, mitochondrial [Source:RGD Symbol;Acc:1593058] |
| Ensembl ID | ENSRNOG00000048843 |
| Bio databases IDs | |
| Aliases | Ts translation elongation factor, mitochondrial |
| Synonyms | 2310050B20RIK, 2A3-2, 9430024O13Rik, EF-TS, EFTSMT, Ts translation elongation factor, mitochondrial |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tsfm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Elongation factor TS
- protein binding
- translation elongation factor Ts
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- insulin resistance
- encephalomyopathy with respiratory failure and lactic acidosis
- primary dilated cardiomyopathy
- hereditary disorder
- Leigh syndrome
- multiple sclerosis
- mitochondrial disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tsfm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription elongation, DNA-dependent
- mitochondrial translational elongation
- translational elongation
- regulation of mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation elongation factor activity