Ndufa9 Gene Summary [Rat]
Predicted to enable NADH dehydrogenase activity. Involved in response to glucose. Predicted to be located in mitochondrial matrix and mitochondrial membrane. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa9 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A9 [Source:RGD Symbol;Acc:1307307] |
| Ensembl ID | ENSRNOG00000061684 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A9 |
| Synonyms | 1010001N11Rik, 39 Kda, ci, CC6, CI-39k, Complex I-39KD, COQ11, MC1DN26, Nadh-ubiquinone oxidoreductase 39-kda subunit, NADH:ubiquinone oxidoreductase subunit A9, NADH UBIQUINONE OXYDOREDUCTASE, ND39, NDUFS2L, SDR22E1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufa9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3-beta hydroxysteroid dehydrogenase/isomerase family
- binding protein
- NAD dependent epimerase/dehydratase family
- NADH2 dehydrogenase
- enzyme
- protein binding
- NmrA-like family
Pathways
Biological processes and signaling networks where the Ndufa9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- nuclear type 26 mitochondrial complex I deficiency
- hereditary disorder
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- Leigh syndrome
- adult acute myeloid leukemia
regulates
- Mitochondrial ETC 1
role in cell
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufa9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- circadian rhythm
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- respiratory chain complex I
- mitochondrial membrane
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase activity
- NADH dehydrogenase (ubiquinone) activity