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GeneGlobe ID: JHS-3001Z | Cat. No.: | QIAseq RNA Fusion XP Panels

QIAseq RNA Fusion XP Oncology Research Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

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Product Specification

Target List

Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.

Bone Cancer
Askins Tumors​
ERGEWSR1FLI1FUS
Ewing's Sarcomas​
ERGETV1ETV4EWSR1FEVFLI1FUSNFATC2SMARCA5
Giant Cell Tumors​
EWSR1FLI1
Mesenchymal Chondrosarcomas​
CDX1HEY1IRF2BP2NCOA2
Myxoid Chondrosarcomas​
EWSR1NR4A3 (NOR1)TAF15TCF12TFG
Brain Cancer
Gliomas​
AKT2BRAFCLCN6FAM131BFGFR1FGFR3FIP1L1GNAI1GOPCMKRN1MYBPDGFRAPRKCBRAF1RNF130ROS1SRGAP3TACC1TACC3
Neuroblastomas​
EWSR1FLI1
Pilocytic Astrocytomas​
CLCN6FAM131BGNAI1MKRN1RNF130SRGAP3TACC1
Other Brain Cancers​
EWSR1FLI1NAB2PDGFRAPRKCASTAT6
Breast Cancer
Carcinomas​
AKT2BRD3DAZLETV6FGFR1JAK1KIT (CD117)MAST1MAST2NTRK3PIK3CA (p110-alpha)RAF1TBL1XR1ZC3H7BZNF703
Ductal Carcinomas​
DAZLETV6NTRK3
Other Breast Cancers​
AKT3ESR1 (ERα)NOTCH2
Colorectal Cancer
Adenocarcinomas​
ETV6INSRNTRK1NTRK3TCF7L2TPM3VTI1A
Kidney Cancer
Carcinomas​
ALKASPSCR1PRCCTFE3VCL
Clear Cell Sarcomas​
TERT
Mesoblastic Nephromas​
ETV6NTRK3
Renal Cell Carcinomas​
TFEBVCL
Leukemia
Acute Leukemia of Ambiguous Lineage​
ABL1AFF1BCRCT45A2ETV6EWSR1GPHNKMT2AMLLT10MN1NUP214PBX1SETTCF3ZNF384
Acute Lymphoblastic Leukemia (ALL)​
ABL1ABL2 (ARG)ACTN4AFDNAFF1AFF3AFF4AGGF1ANLNASNSATF7IPAUTS2BCL11BBCL9BCRBTBD18CASC5CREBBP (CBP)CRLF2 (TSLPR)CSF1RDDX3XEBF1ELLELNEML1EP300EPOREPS15ESRRBETV6EWSR1FGFR1FGFR1OPFLT3FOXO4FOXP1FRYLGAS7GPHNHLFHNRNPUL1IL2RBINPP5DJAK2KMT2AKMT2ELNP1MAML2MEF2DMLLT1MLLT10MLLT3MN1MNX1MYBMYCNCOA2NOTCH1NUP214NUP98P2RY8PAG1PAX5PBX1PCM1PDGFRBPICALMPMLPRDM16RAP1GDS1RARARCSD1RUNX1 (AML1)SALL2SETSFPQSPI1SSBP2STILSTMN1TAF15TAL1TCF3TCF7TET1TSLPTYK2USP9XZBTB16ZCCHC7ZMIZ1ZMYM2ZNF384ZNF521
Acute Myeloid Leukemia (AML)​
ABI1ABI2ABL1AFDNAFF1AFF4ALKANLNARHGAP26ARHGEF12BCORBCRCASC5CBFA2T3CBFBCBLCCDC88CCEP170BCHD1CHIC2CREBBP (CBP)DAB2IPDDX10DEKDHHDIAPH2ELLEP300EPS15ERGETV6FGFR1FIP1L1FLNAFNBP1FOXO3FOXO4FRYLFUSGAS7GATA1GLIS2GPHNHAUS1HOXA9HOXC11HOXC13HOXD13IRF2BP2JAK2KAT6AKDM5AKIAA1524KIT (CD117)KMT2ALASP1LNP1LPPLYNMAML2MECOMMKL1MLF1MLLT1MLLT10MLLT11MLLT3MLLT6MN1MNX1MYBMYH11MYO1FNCKIPSDNCOA2NF1NPM1NSD1NTRK3NUMA1NUP214NUP98PAN3PBX1PCM1PDGFRAPDGFRBPDS5APHF23PICALMPMLPRDM16PRRX1PSIP1PSMA2PTPRRRANBP2RARARBM15RHEBL1RPL22RPN1RUNX1 (AML1)RUNX1T1SARNPSEPT2SEPT5SEPT6SEPT9SETSH3GL1SORBS2STAT5BTAF15TCF3TET1TFGTOP1TOP3ATRIP11TYK2UBA2USP42WHSC1L1WTIPZBTB16ZFYVE19ZNF384
Acute Myelomonocytic Leukemia (AMML)​
FLNAHOXD13NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)​
ABL1ACTN4AFF1AFF3AFF4ATF7IPBCRBTBD18CRLF2 (TSLPR)EPS15ERGESRRBETV6EWSR1FUSGAS7JAK2KMT2AMAPRE1MLLT1NUP214P2RY8PAX5PBX1PCM1RUNX1 (AML1)SETSSBP2TCF3USP9XZNF384ZNF521
Blast Phase Chronic Myeloid Leukemia​
ABL1BCRETV6JAK2
Chronic Eosinophilic Leukemia​
ACSL6TNIP1
Chronic Lymphocytic Leukemia (CLL)​
MYCNOTCH1
Chronic Myeloid Leukemia (CML)​
ABL1BCRCCDC88CETV6HOXA11HOXA13JAK2MECOMMN1NDE1NUP98PCM1PDGFRBRUNX1 (AML1)
Chronic Myelomonocytic Leukemia (CMML)​
CREBBP (CBP)ELLETV6KMT2AMN1
Myelodysplastic Syndromes (MDS)​
ABL1ACTN4ALKCASC5CREBBP (CBP)DEKERGETV6FRYLFUSHOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1NDE1NPM1NUP214NUP98PCM1PDGFRBPRDM16PTPRRRANBP2RUNX1 (AML1)RUNX1T1TOP1
Myeloproliferative Neoplasms​
ABL1ACSL6BCRETV6FGFR1FGFR1OPFIP1L1FLT3HOXA9HOXD13JAK2LYNMECOMMLF1MN1NPM1NUP98PDGFRBPRKG2PSIP1RARARUNX1 (AML1)TNIP1ZMYM2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)​
ABL1AFDNAGGF1ASNSBCL11BBCRCASC5DDX3XETV6JAK2KMT2AKMT2EMLLT1MLLT10NOTCH1NUP214PBX1RUNX1 (AML1)SALL2SETSPI1STILSTMN1TAL1TCF3TCF7
Other Leukemias​
BCL11BIKZF2IKZF3IRF2BP2MYCNPM1PDCD1LG2SETD2TYK2
Liver Cancer
Cholangiocarcinomas​
CCDC6FGFR2TACC3
Hepatocellular Carcinomas​
PKN1
Lung Cancer
Acinar Adenocarcinomas​
ALKCD74EML4HIP1KIF5BROS1SDC4
Adenocarcinomas​
ALKBAIAP2L1BCL11ABRAFCCDC6CD74CUX1EML4ERBB2 (HER-2, NEU)ERBB4EZRFGFR2FGFR3GCC2GOPCHIP1HLA-DRB1KIAA1217KIF5BKLC1LRIG3METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK2PBX1PRKCBRETROS1SDC4SLC34A2SND1STARD3NLSTRNTACC3TCF3TFGTPM3TPRTRIM24TRIM33
Bronchioloalveolar Adenocarcinomas​
ALKEML4KLC1PBX1ROS1SDC4TCF3
Inflammatory Myofibroblastic Tumors​
ALKCD74EML4EZRGOPCLRIG3PPFIBP1ROS1SDC4SLC34A2TPM3
Invasive Mucinous Adenocarcinomas​
ALKCD74EML4NRG1 (HGL)SLC3A2
Mixed Adenosquamous Carcinomas​
ALKEML4KIF5BRET
Mucoepidermoid Carcinomas​
ALKCRTC1EML4MAML2
Non-Small Cell Carcinomas​
ALKBCL11ACCDC6CD74CUX1EGFR (ERBB1)EML4EZRGCC2GOPCHIP1KIAA1217KIF5BKLC1LRIG3NCOA4RETROS1SDC4SLC34A2STRNTFGTPM3TPRTRIM33
Non-Small Cell Lung Cancers (NSCLC)​
ALKBAG4BAIAP2L1BCL11ACCDC6CD74CLIP4CUX1DNAH5EGFR (ERBB1)EML4ETV6EZRFERFGFR1FGFR3GCC2GLRX5GOPCHIP1HLA-DRB1IRF2BP2KIAA1217KIF5BKLC1LRIG3MAN2A1METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK3RAD51RETROS1RUNX1 (AML1)SDC4SLC34A2SLC3A2SQSTM1STRNTACC3TFGTPM3TPRTRA2BTRIM33VSNL1
Squamous Cell Carcinomas (SCC)​
ALKBAIAP2L1CD74EML4FGFR2FGFR3FGRHIP1KIF5BKIT (CD117)NRG1 (HGL)PKN1PRKCAPRKCBRETTACC3
Other Carcinomas​
ALKBRD4EML4NUTM1
Other Lung Cancers​
ARL17ABAG4BAIAP2L1CCDC6CD74CUX1EZRFGFR1FGFR3GOPCIRF2BP2KANSL1KIAA1217KIF5BLRIG3MPRIPNCOA4NRG1 (HGL)NTRK1NUTM1PTPRKRETROS1RSPO3SDC4SLC34A2SLC3A2SQSTM1TACC3TPM3TPRTRIM33WHSC1L1
Lymphoma
Acute Lymphoblastic Lymphomas​
BCL11BCREBBP (CBP)EBF1KMT2AMLLT10MYCP2RY8PRDM16STIL
Anaplastic Large Cell Lymphomas​
ADGRG7ALKATICCLTCMSNMYCNPM1TFGTPM3TPM4
Angioimmunoblastic T Cell Lymphomas​
CD28CTLA4FIP1L1PDGFRA
Burkitt Lymphomas​
BCL6MYCPBX1TCF3
Diffuse Large B Cell Lymphomas (DLBCL)​
ALKBCL11ABCL6CCND3CIITACLTCIGLL5LPPMAPK13 (p38delta)MYCNPM1PIM1RELSQSTM1TBL1XR1TOMM40TP63ZCCHC7
Follicular Lymphomas​
AFF3BCL2BCL6CIITAMYCTBL1XR1TP63
Granulocytic Sarcomas​
RUNX1 (AML1)RUNX1T1
Hodgkin Lymphomas​
ALKCIITAJAK2NPM1SEC31A
Inflammatory Myofibroblastic Tumors​
ALKCARSDCTN1
Lymphoblastic Lymphomas​
BCRCRLF2 (TSLPR)EPORETV6FGFR1NOTCH1PBX1PDGFRBRARATERTZCCHC7
Lymphoblastic T Cell Lymphomas​
BCRETV6FGFR1FIP1L1LYNPDGFRA
Mantle Cell Lymphomas​
CCND3MYC
Mediastinal Large B Cell Lymphomas (MLBL)​
CIITAPDCD1LG2
Mediastinal Large B-Cell Lymphomas​
CIITAPDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas​
BCL6BIRC3 (c-IAP2)CCND3MALT1MYC
Peripheral T Cell Lymphomas​
ALKETV6FGFR3IKZF2ITKMYO1FNPM1S100A7SYKTBL1XR1THAP4TP63VAV1
Precursor T Cell Lymphoblastic Lymphomas​
ABL1JAK2NUP214PCM1SET
T Cell Lymphomas​
ATXN2LBCL11BFGFR1IKZF2JAK2
Other Lymphomas​
ALKATXN2LBCL6BIRC3 (c-IAP2)CBFBCCND1CCND3CDK6CHIC2CLTCDEKDUSP22EIF4A1JAK2KMT2AMALT1MKL1MLF1MLLT10MYCNFKB2NPM1PICALMPRDM16
Myelodysplastic Syndromes (MDS)
ABL1ACTN4ALKCASC5CREBBP (CBP)DEKDIAPH2ERGETV6FGFR1FRYLFUSGOT1HOXA11HOXA13HOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1MYH11NDE1NPM1NUP214NUP98PAN3PCM1PDGFRBPRDM16PSMA2PTPRRRANBP2RUNX1 (AML1)RUNX1T1SEPT9SYKTOP1ZMYM2
Myeloproliferative Neoplasms
ABL1ACSL6BCRCNTRLETV6FGFR1FGFR1OPFIP1L1FLT3FOXP1HOXA9HOXD13JAK2KANK1LYNMECOMMLF1MN1NPM1NUP98PCM1PDGFRAPDGFRBPRKG2PSIP1RARARUNX1 (AML1)TNIP1
Ovarian Cancer
Carcinomas​
ESRRA
Serous Cyst Adenocarcinomas​
AKT2AXLFGRINSRJAK1
Pancreatic Cancer
Acinar Cell Carcinomas​
GATMHACL1HERPUD1SND1ZSCAN30
Adenocarcinomas​
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2 (hGK-1, hK2)KRASNDRG1PIK3CA (p110-alpha)RAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Carcinomas​
BRAFRAF1
Prostate Cancer
Adenocarcinomas​
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2 (hGK-1, hK2)KRASNDRG1PIK3CA (p110-alpha)RAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Glandular Intraepithelial Neoplasia​
ERGTMPRSS2
Other Carcinomas​
ERGETV1TMPRSS2
Salivary Gland Cancer
Adenomas​
FGFR1PLAG1
Mucoepidermoid Carcinomas​
CRTC1MAML2
Warthin Tumors​
CRTC1MAML2
Other Carcinomas​
ETV6NTRK3
Other Salivary Gland Cancers​
MYB
Sarcoma
Alveolar Soft Part Sarcomas​
ASPSCR1TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas​
CAMTA1CEP85LCICLEUTXROS1TFE3YAP1
Askins Tumors​
ERGEWSR1FLI1FUS
Chondrosarcomas​
ACVR2ACDX1EWSR1FN1HEY1IRF2BP2NCOA2NR4A3 (NOR1)TAF15TCF12TFG
Clear Cell Sarcomas​
ATF1CREB1EWSR1FLI1NUTM2BYWHAE
Congenital (Infantile) Fibrosarcomas​
ETV6METNTRK3TFG
Dermatofibrosarcoma Protuberans​
COL1A1PDGFB
Dermatofibrosarcomas Protuberans​
COL1A1PDGFB
Desmoplastic Small Round Cell Tumors​
ERGEWSR1FLI1PATZ1WT1
Endometrial Stromal Sarcomas​
ALKBCORCXorf67EPC1FN1JAZF1MBTD1MEAF6NUTM2ANUTM2BPHF1SUZ12YWHAEZC3H7B
Epithelioid Sarcomas​
CREB3L1CREB3L2EWSR1FUSKLF17SS18SSX1
Ewing's Sarcomas​
CICERGETV1ETV4EWSR1FEVFLI1FOXO4FUSNFATC2SMARCA5SP3
Fibrosarcomas​
BRAFCOL1A1CREB3L1CREB3L2EWSR1FUSLMNANTRK1PDGFBTOM1L2
Leiomyosarcomas​
EWSR1HMGA2PBX3WT1
Liposarcomas​
DDIT3 (GADD153, CHOP)EWSR1FUSHMGA2LGR5NUP107TERT
Myofibroblastic Sarcomas​
ALKLMNANTRK1RELAROS1SRFTFGTPM3YWHAE
Myxofibrosarcomas​
CREB3L1CREB3L2FUS
Myxoid Chondrosarcomas​
NR4A3 (NOR1)TAF15
Perivascular Epithelioid Cell Tumors (PEComa)​
DVL2SFPQTFE3
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)​
CITED2MED12PRDM10
Rhabdoid Tumors​
NCOA4RET
Rhabdomyosarcomas​
CITED2EWSR1FLI1FOXO1NCOA1NCOA2PAX3PAX7SRFTEAD1VGLL2
Small Round Cell Tumors​
ERGETV1EWSR1FEVFLI1FOXO1PAX3
Solitary Fibrous Tumors​
NAB2STAT6
Synovial Sarcomas​
COL6A3CSF1 (MCSF)S100A10SS18SS18L1SSX1SSX2SSX2BSSX4B
Undifferentiated; Unclassified or Other Sarcomas​
ATF1BCORBRD4CCNB3CREMERGETV4EWSR1FGF1FGFR1FLI1FN1FOXO1FUSGLI1JAZF1MAML3MKL2NPM1NUTM1PAX3PLAG1POU5F1 (OCT4)RUNX1 (AML1)RUNX1T1SUZ12USP6
Skin Cancer
Adnexal Tumors; Hidradenomas​
CRTC1MAML2
Atypical Spitzoid Tumors​
ALKTPM3
Benign Melanocytic Nevus​
ALKBRAFCEP89ERC1FCHSD1GOLGA5KIF5BLSM14AMYO5APPFIBP1PWWP2ARETROS1TPM3
Melanomas​
AGKATF1BRAFCREB1EWSR1FCHSD1FGRPAPSS1TRIM24
Spitzoid Melanomas​
CEP89LSM14AMYO5APPFIBP1PWWP2A
Soft Tissue Cancer
Clear Cell Sarcomas​
ATF1EWSR1
Congenital (Infantile) Fibrosarcomas​
ETV6NTRK3
Desmoplastic Small Round Cell Tumors​
ERGEWSR1SSX1
Endometrial Stromal Sarcomas​
ALKFN1
Epithelioid Sarcomas​
SS18
Inflammatory Myofibroblastic Tumors​
ALKATICCARSCLTCDCTN1PPFIBP1RANBP2SEC31ATPM3TPM4
Leiomyosarcomas​
EWSR1WT1
Liposarcomas; Myxoid-Round Cell​
DDIT3 (GADD153, CHOP)EWSR1
Liposarcomas; Pleomorphic​
DDIT3 (GADD153, CHOP)FUS
Rhabdoid Tumors​
NCOA4RET
Rhabdomyosarcomas​
FOXO1PAX3PAX7
Sarcomas​
ETV4EWSR1
Small Round Cell Tumors​
ETV1EWSR1FEVFLI1
Solitary Fibrous Tumors​
NAB2STAT6
Synovial Sarcomas​
SS18SSX2SSX2B
Other Fibrosarcomas​
COL1A1PDGFB
Stomach Cancer
Adenocarcinomas​
AKT1ERBB2 (HER-2, NEU)INSR
Thyroid Cancer
Adenoma-Nodule-Goitre​
CCDC6NCOA4PAX8PPARGPRKAR1ARET
Anaplastic Carcinomas​
ALKCCDC6NCOA4RETSTRN
Follicular Carcinomas​
PAX8PPARG
Hurthle Cell Carcinomas​
CCDC6NCOA4RET
Mucoepidermoid Carcinomas​
CRTC1MAML2
Papillary Carcinomas​
AGKAKAP9ALKBRAFCCDC6EML4ERC1ETV6GOLGA5HOOK3KTN1NCOA4NTRK1NTRK3PAX8PCM1PPARGPRKAR1ARETSTRNTFGTPM3TRIM24TRIM27TRIM33
Urinary Tract Cancer
Endometrial Carcinomas​
INSRPIK3CA (p110-alpha)
Transitional Cell Carcinomas​
BAIAP2L1FGFR3TACC3
Uterine Cancer
Endometrial Carcinomas​
INSRPIK3CA (p110-alpha)
Other Hematological Malignancies
Eosinophilia​
ETV6FOXP1LYNPDGFRA
Langerhans Cell Histiocytosis​
NTRK3PLEKHA6
Plasma Cell Myelomas​
ABL1BCR
Polycythemia Vera​
GTF2H3
Severe Thrombocythemia​
KANK1PDGFRB
Other Myeloid Neoplasms
KLF2PTK2B (PYK2)SEMA6A
Other Solid Tumors
Midline Carcinomas​
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)​
MAST2
Other Solid Tumors​
ARHGAP26BRD3INSRMAST2MSMBMUSKNUMBLNUTM1PDGFRBRSPO2THADA
Other Cancers
Midline Carcinomas​
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)​
MAST2
Other Cancers​
JAK3
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFR (ERBB1)EML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells​
CD200CD274 (PD-L1)CD274 (PD-L1)CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR
Stimulatory on Tumor Cells​
CD40 (TNFRSF5)CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4 (OX40L)TNFSF9
Inhibitory on T Cells​
BTLACD160CD200R1CD244CD274 (PD-L1)CD274 (PD-L1)CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1 (PD1)PDCD1 (PD1)VSIR
Stimulatory on T Cells​
CD244CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD40LGICOSTNFRSF14TNFRSF18TNFRSF4 (OX40)TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes​
CD247CD3DCD3ECD3GTRACTRGC2
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30
Other Checkpoint Molecules​
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1 (IDO)IDO1 (IDO)IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25 (DR3)TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACD274 (PD-L1)CD274 (PD-L1)CD80CD8ACSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2 (HER-2, NEU)FASIL5RA (CD125)INHBATNFRSF8TNFSF4 (OX40L)TNFSF9
Immuno Stimulatory Gene Signature
CD160CD19CD200CD27 (TNFRSF7)CD44CTLA4HLA-AIL12RB2IL17AKIT (CD117)TNFRSF17
Immuno Suppressive Gene Signature
CD274 (PD-L1)CD274 (PD-L1)CD276HAVCR2PDCD1LG2TGFB1
Upregulated in Cancer Vaccination Response
CCL5 (RANTES)CD3DCD86CD8ACXCL10 (INP10)CXCL9 (MIG)GBP1ICOSIRF1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells​
CD8ACD8BFLT3LGGZMMPRF1
Th1 Cells​
CCL4 (MIP-1B)CD38CD70CSF2 (GM-CSF)CTLA4DPP4IFNGIL12RB2LTA (TNFB)STAT4TBX21
Th17 Cells​
IL17AIL17RARORC
Th2 Cells​
CXCR6GATA3IL26LAIR2MAFPMCHSMAD2 (MADH2)STAT6
Follicular Helper T Cells​
BCL6CXCL13MAFPDCD1 (PD1)PDCD1 (PD1)
Other T Helper Cell Markers​
ANP32BBATFCD28ICOSNUP107
Regulatory T Cells​
FOXP3
Gamma Delta T Cells​
CD160FEZ1TRGC1
Central Memory T Cells​
ATMDOCK9FYB1NEFLREPS1TXKUSP9Y
Effector Memory T Cells​
AKT3CCR2EWSR1IL15RALTKNFATC4 (NFAT3)
Other T Cell Markers​
CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25 (DR3)TRACTRGC2
Myeloid Derived Suppressor Cells​
TGFB1
Cytotoxic Lymphocytes​
CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21
Natural Killer Cells​
BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205
Activated Dendritic Cells​
CCL1 (I-309)EBI3LAMP3OAS3
Immature Dendritic Cells​
CD1ACD1BCD1EF13A1SYT17
Myeloid Dendritic Cells​
CD1ACD1BCD1E
Plasmacytoid Dendritic Cells​
IL3RA
Other Dendritic Cell Markers​
CCL13 (MCP-4)CCL17 (TARC)CCL22 (MDC)CD209HSD11B1
Macrophages​
APOECCL7 (MCP-3)CD68CHIT1CXCL5 (ENA-78, LIX)MARCOMSR1
Neutrophils​
CSF3R (GM-CSFR)FPR2MME
Eosinophils​
CCR3IL5RA (CD125)PTGDR2 (CRTH2, GPR44)SMPD3THBS1 (TSP-1)
Mast Cells​
CMA1CTSGKIT (CD117)MS4A2PRG2TPSAB1
B Cells​
BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17
Antigen Presenting Cells​
CMKLR1
Regulatory T Cell Gene Signature
CD274 (PD-L1)CD274 (PD-L1)JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4 (OX40)TNFRSF8TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
CCL5 (RANTES)CX3CL1CXCL10 (INP10)CXCL9 (MIG)ITGB2SELL (LECAM-1)
Other T Cell Trafficking & Infiltration into Tumors Genes​
CCL17 (TARC)CCL4 (MIP-1B)CCR3CCR6CD274 (PD-L1)CD274 (PD-L1)CD44CSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)CXCL13FOXP3IFNGITGA4 (CD49D)ITGB7LTA (TNFB)PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTENTNFRSF25 (DR3)TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
CCL5 (RANTES)CD200CD27 (TNFRSF7)CD69CTLA4CXCL10 (INP10)CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1 (ABCB2)TIGITTNFRSF9
Downregulated in T Cell Exhaustion​
TNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes​
BATFTBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
APPCAPZBCCL4 (MIP-1B)CCL5 (RANTES)CD8ACSNK1ECTLA4CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL9 (MIG)EBI3EHD1GBA2GZMBHLA-DQA1IDO1 (IDO)IDO1 (IDO)IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3 (MADH3)TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers​
ADAM28AKNAAOAHARHGAP9CACNA2D2CARD11CARD16CD109CLEC11ACORO1ACORO1BCXCR4FLT3FMNL1HIVEP1HIVEP2IFI44LIFITM1 (9-27)IGHA1IGHMIGSF6IKZF1ITPKALSM4LST1MAP3K14NFAM1NFKBIL1PLA2G2DPOU2AF1 (OCA-B)PTPRCAPSERPINB9SH3BP5SYTL1TMC8TNFRSF13BTNFRSF19ZFYVE9
Expression Correlates with Positive Objective Response Rates​
CD274 (PD-L1)CD274 (PD-L1)CD276CTLA4HAVCR2IDO1 (IDO)IDO1 (IDO)LAG3PDCD1LG2VTCN1
Upregulated during Treatment​
CD8ACTLA4CXCL10 (INP10)EOMESGZMAGZMBICOSIFNGPRF1
Regulated during Treatment​
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response​
ADAM17 (CD156B)MYCRHOCTIMP1
Other Pre-Treatment Response Predictors​
CDK2CDKN2A (P16INK4A)LARGE1NAB2NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing​
BTLACD274 (PD-L1)CD274 (PD-L1)CD80HAVCR2IDO1 (IDO)IDO1 (IDO)IDO2LAG3MICAMICBPDCD1 (PD1)PDCD1 (PD1)TGFB1VSIRVTCN1
Stimulates Cancer Cell Killing​
IFNG
Antigen Processing & Presentation
Proteasome​
PSMB10PSMB9
Proteases​
IFI30
Endoplasmic Reticulum & Lysosomal Transport​
TAP1 (ABCB2)TAP2 (ABCB3)TAPBPL
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
Immune Cell Receptors & Co-Receptors​
CD8ACD8BKIR3DL1KLRC1KLRD1
Stimulates Antigen Presentation​
CD40 (TNFRSF5)CD40LG
Interferon Gamma Response
Cytokines & Chemokines​
CCL5 (RANTES)IL15RASTAT1
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes​
HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
RNA Degradation​
OAS3
Transcription Factors​
IRF1IRF2
Other Interferon Gamma Response Genes​
CD44GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons​
CCL4 (MIP-1B)CCL5 (RANTES)CXCL10 (INP10)
Oncogenes
ABL1AKT1ALKARBCL2BRAFCBLCTNNB1DNMT3AEGFR (ERBB1)ERBB2 (HER-2, NEU)EZH2FGFR2FGFR3FLT3FOXL2GATA2GNA11GNAQGNASH3-3AH3C2HRASIDH1IDH2JAK1JAK2JAK3KIT (CD117)KRASMAP2K1MED12METMPLMYD88NFE2L2NRASPDGFRAPIK3CA (p110-alpha)PPP2R1APTPN11RETSETBP1SF3B1SMOSPOPSRCSRSF2TSHRU2AF1
Tumor Suppressor Genes
ACVR1BAMER1APCARID1AARID2ASXL1ATMB2MBCORCDKN2A (P16INK4A)CICCREBBP (CBP)DAXXFBXW7KMT2DMLH1NOTCH2PAX5PBRM1PIK3R1 (p85-ALPHA)PTENRUNX1 (AML1)SMAD2 (MADH2)SMAD4 (MADH4)SMARCB1STK11 (LKB1)WT1
Cell Adhesion Molecules
ABL1APCCSF3R (GM-CSFR)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)JAK2PDGFRAPTENPTPN11RAC1RETRHOASRC
Angiogenesis
CTNNB1ERBB2 (HER-2, NEU)FGFR2GATA2PIK3CA (p110-alpha)PLCG1PTENRUNX1 (AML1)
Apoptosis
ABL1APCBCL2BRAFCBLCTNNB1DAXXFLT3FOXL2HRASID3MYCNPTENRAD21RAF1STK11 (LKB1)WT1
Cell Cycle
ABL1AKT1APCCDKN2A (P16INK4A)CHEK2 (RAD53)CREBBP (CBP)CUX1FBXW7FGFR2HRASID3MYCPTENRAD21RHOASMARCB1STK11 (LKB1)XPO1
DNA Damage & Repair
ABL1APCATMCHEK2 (RAD53)MLH1POLERAD21STK11 (LKB1)
Epigenetics
ARID1AARID2ASXL1BCORDICER1DNMT3AEZH2H3-3AH3C2KMT2DNSD2PBRM1SETBP1SMARCB1SPOP
Hypoxia Signaling
CREBBP (CBP)EPAS1SMAD4 (MADH4)
Immune Response
ALKB2MBTKCBLBCD79BCREBBP (CBP)CXCR4JAK1JAK2JAK3MAP2K1MAP2K2 (MEK2)MYD88PAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11
Inflammatory Response
CXCR4JAK2MYD88
Metabolism
IDH1IDH2
mRNA Splicing
SF3B1SRSF2U2AF1ZRSR2
Signal Transduction
AKT & PI3 Kinase Signaling​
AKT1CBLERBB2 (HER-2, NEU)FLT3JAK2KIT (CD117)PDGFRAPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTEN
Fibroblast Growth Factor Signaling​
AKT1FGFR1FGFR2FGFR3FGFR4PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11SRC
G-Protein Coupled Receptor Signaling​
AKT1GNA11GNAQGNASSMOTSHR
Hormone Receptors​
ARESR1 (ERα)
JAK / STAT Signaling​
JAK1JAK2JAK3STAT3
MAP Kinase Signaling​
MAP2K1MAP2K2 (MEK2)MAPK1 (ERK2)NRASPPM1DRAF1
Notch Signaling​
FBXW7GATA2NOTCH2
Receptor Tyrosine Kinases​
ALKEGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3FGFR1FGFR4FLT3KIT (CD117)PDGFRARET
TGFb Signaling​
ACVR1BSMAD2 (MADH2)
WNT Signaling​
AMER1APCCTNNB1MED12PPP2R1A
Other Signal Transduction Genes​
KRASMETSMAD4 (MADH4)
Transcription Factors
ARCICCUX1ESR1 (ERα)FBXW7FOXL2GATA2ID3MYCMYCNNFE2L2NKX2-1PAX5RUNX1 (AML1)WT1
Ubiquitination
BCORCBLBDAXX
Unfolded Protein Response
NFE2L2
Other Cancer Related Genes
DNM2MPLPRSS1TERT

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