Target List
Bone Cancer
Askins Tumors
ERG, EWSR1, FLI1, FUS
Ewing's Sarcomas
ERG, ETV1, ETV4, EWSR1, FEV, FLI1, FUS, NFATC2, SMARCA5
Giant Cell Tumors
EWSR1, FLI1
Mesenchymal Chondrosarcomas
CDX1, HEY1, IRF2BP2, NCOA2
Myxoid Chondrosarcomas
EWSR1, NR4A3 (NOR1), TAF15, TCF12, TFG
Brain Cancer
Gliomas
AKT2, BRAF, CLCN6, FAM131B, FGFR1, FGFR3, FIP1L1, GNAI1, GOPC, MKRN1, MYB, PDGFRA, PRKCB, RAF1, RNF130, ROS1, SRGAP3, TACC1, TACC3
Neuroblastomas
EWSR1, FLI1
Pilocytic Astrocytomas
CLCN6, FAM131B, GNAI1, MKRN1, RNF130, SRGAP3, TACC1
Other Brain Cancers
EWSR1, FLI1, NAB2, PDGFRA, PRKCA, STAT6
Breast Cancer
Carcinomas
AKT2, BRD3, DAZL, ETV6, FGFR1, JAK1, KIT (CD117), MAST1, MAST2, NTRK3, PIK3CA (p110-alpha), RAF1, TBL1XR1, ZC3H7B, ZNF703
Ductal Carcinomas
DAZL, ETV6, NTRK3
Other Breast Cancers
AKT3, ESR1 (ERα), NOTCH2
Colorectal Cancer
Adenocarcinomas
ETV6, INSR, NTRK1, NTRK3, TCF7L2, TPM3, VTI1A
Kidney Cancer
Carcinomas
ALK, ASPSCR1, PRCC, TFE3, VCL
Clear Cell Sarcomas
TERT
Mesoblastic Nephromas
ETV6, NTRK3
Renal Cell Carcinomas
TFEB, VCL
Leukemia
Acute Leukemia of Ambiguous Lineage
ABL1, AFF1, BCR, CT45A2, ETV6, EWSR1, GPHN, KMT2A, MLLT10, MN1, NUP214, PBX1, SET, TCF3, ZNF384
Acute Lymphoblastic Leukemia (ALL)
ABL1, ABL2 (ARG), ACTN4, AFDN, AFF1, AFF3, AFF4, AGGF1, ANLN, ASNS, ATF7IP, AUTS2, BCL11B, BCL9, BCR, BTBD18, CASC5, CREBBP (CBP), CRLF2 (TSLPR), CSF1R, DDX3X, EBF1, ELL, ELN, EML1, EP300, EPOR, EPS15, ESRRB, ETV6, EWSR1, FGFR1, FGFR1OP, FLT3, FOXO4, FOXP1, FRYL, GAS7, GPHN, HLF, HNRNPUL1, IL2RB, INPP5D, JAK2, KMT2A, KMT2E, LNP1, MAML2, MEF2D, MLLT1, MLLT10, MLLT3, MN1, MNX1, MYB, MYC, NCOA2, NOTCH1, NUP214, NUP98, P2RY8, PAG1, PAX5, PBX1, PCM1, PDGFRB, PICALM, PML, PRDM16, RAP1GDS1, RARA, RCSD1, RUNX1 (AML1), SALL2, SET, SFPQ, SPI1, SSBP2, STIL, STMN1, TAF15, TAL1, TCF3, TCF7, TET1, TSLP, TYK2, USP9X, ZBTB16, ZCCHC7, ZMIZ1, ZMYM2, ZNF384, ZNF521
Acute Myeloid Leukemia (AML)
ABI1, ABI2, ABL1, AFDN, AFF1, AFF4, ALK, ANLN, ARHGAP26, ARHGEF12, BCOR, BCR, CASC5, CBFA2T3, CBFB, CBL, CCDC88C, CEP170B, CHD1, CHIC2, CREBBP (CBP), DAB2IP, DDX10, DEK, DHH, DIAPH2, ELL, EP300, EPS15, ERG, ETV6, FGFR1, FIP1L1, FLNA, FNBP1, FOXO3, FOXO4, FRYL, FUS, GAS7, GATA1, GLIS2, GPHN, HAUS1, HOXA9, HOXC11, HOXC13, HOXD13, IRF2BP2, JAK2, KAT6A, KDM5A, KIAA1524, KIT (CD117), KMT2A, LASP1, LNP1, LPP, LYN, MAML2, MECOM, MKL1, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MN1, MNX1, MYB, MYH11, MYO1F, NCKIPSD, NCOA2, NF1, NPM1, NSD1, NTRK3, NUMA1, NUP214, NUP98, PAN3, PBX1, PCM1, PDGFRA, PDGFRB, PDS5A, PHF23, PICALM, PML, PRDM16, PRRX1, PSIP1, PSMA2, PTPRR, RANBP2, RARA, RBM15, RHEBL1, RPL22, RPN1, RUNX1 (AML1), RUNX1T1, SARNP, SEPT2, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SORBS2, STAT5B, TAF15, TCF3, TET1, TFG, TOP1, TOP3A, TRIP11, TYK2, UBA2, USP42, WHSC1L1, WTIP, ZBTB16, ZFYVE19, ZNF384
Acute Myelomonocytic Leukemia (AMML)
FLNA, HOXD13, NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
ABL1, ACTN4, AFF1, AFF3, AFF4, ATF7IP, BCR, BTBD18, CRLF2 (TSLPR), EPS15, ERG, ESRRB, ETV6, EWSR1, FUS, GAS7, JAK2, KMT2A, MAPRE1, MLLT1, NUP214, P2RY8, PAX5, PBX1, PCM1, RUNX1 (AML1), SET, SSBP2, TCF3, USP9X, ZNF384, ZNF521
Blast Phase Chronic Myeloid Leukemia
ABL1, BCR, ETV6, JAK2
Chronic Eosinophilic Leukemia
ACSL6, TNIP1
Chronic Lymphocytic Leukemia (CLL)
MYC, NOTCH1
Chronic Myeloid Leukemia (CML)
ABL1, BCR, CCDC88C, ETV6, HOXA11, HOXA13, JAK2, MECOM, MN1, NDE1, NUP98, PCM1, PDGFRB, RUNX1 (AML1)
Chronic Myelomonocytic Leukemia (CMML)
CREBBP (CBP), ELL, ETV6, KMT2A, MN1
Myelodysplastic Syndromes (MDS)
ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, ERG, ETV6, FRYL, FUS, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, NDE1, NPM1, NUP214, NUP98, PCM1, PDGFRB, PRDM16, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, TOP1
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, HOXA9, HOXD13, JAK2, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PDGFRB, PRKG2, PSIP1, RARA, RUNX1 (AML1), TNIP1, ZMYM2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)
ABL1, AFDN, AGGF1, ASNS, BCL11B, BCR, CASC5, DDX3X, ETV6, JAK2, KMT2A, KMT2E, MLLT1, MLLT10, NOTCH1, NUP214, PBX1, RUNX1 (AML1), SALL2, SET, SPI1, STIL, STMN1, TAL1, TCF3, TCF7
Other Leukemias
BCL11B, IKZF2, IKZF3, IRF2BP2, MYC, NPM1, PDCD1LG2, SETD2, TYK2
Liver Cancer
Cholangiocarcinomas
CCDC6, FGFR2, TACC3
Hepatocellular Carcinomas
PKN1
Lung Cancer
Acinar Adenocarcinomas
ALK, CD74, EML4, HIP1, KIF5B, ROS1, SDC4
Adenocarcinomas
ALK, BAIAP2L1, BCL11A, BRAF, CCDC6, CD74, CUX1, EML4, ERBB2 (HER-2, NEU), ERBB4, EZR, FGFR2, FGFR3, GCC2, GOPC, HIP1, HLA-DRB1, KIAA1217, KIF5B, KLC1, LRIG3, MET, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NTRK2, PBX1, PRKCB, RET, ROS1, SDC4, SLC34A2, SND1, STARD3NL, STRN, TACC3, TCF3, TFG, TPM3, TPR, TRIM24, TRIM33
Bronchioloalveolar Adenocarcinomas
ALK, EML4, KLC1, PBX1, ROS1, SDC4, TCF3
Inflammatory Myofibroblastic Tumors
ALK, CD74, EML4, EZR, GOPC, LRIG3, PPFIBP1, ROS1, SDC4, SLC34A2, TPM3
Invasive Mucinous Adenocarcinomas
ALK, CD74, EML4, NRG1 (HGL), SLC3A2
Mixed Adenosquamous Carcinomas
ALK, EML4, KIF5B, RET
Mucoepidermoid Carcinomas
ALK, CRTC1, EML4, MAML2
Non-Small Cell Carcinomas
ALK, BCL11A, CCDC6, CD74, CUX1, EGFR (ERBB1), EML4, EZR, GCC2, GOPC, HIP1, KIAA1217, KIF5B, KLC1, LRIG3, NCOA4, RET, ROS1, SDC4, SLC34A2, STRN, TFG, TPM3, TPR, TRIM33
Non-Small Cell Lung Cancers (NSCLC)
ALK, BAG4, BAIAP2L1, BCL11A, CCDC6, CD74, CLIP4, CUX1, DNAH5, EGFR (ERBB1), EML4, ETV6, EZR, FER, FGFR1, FGFR3, GCC2, GLRX5, GOPC, HIP1, HLA-DRB1, IRF2BP2, KIAA1217, KIF5B, KLC1, LRIG3, MAN2A1, MET, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NTRK3, RAD51, RET, ROS1, RUNX1 (AML1), SDC4, SLC34A2, SLC3A2, SQSTM1, STRN, TACC3, TFG, TPM3, TPR, TRA2B, TRIM33, VSNL1
Squamous Cell Carcinomas (SCC)
ALK, BAIAP2L1, CD74, EML4, FGFR2, FGFR3, FGR, HIP1, KIF5B, KIT (CD117), NRG1 (HGL), PKN1, PRKCA, PRKCB, RET, TACC3
Other Carcinomas
ALK, BRD4, EML4, NUTM1
Other Lung Cancers
ARL17A, BAG4, BAIAP2L1, CCDC6, CD74, CUX1, EZR, FGFR1, FGFR3, GOPC, IRF2BP2, KANSL1, KIAA1217, KIF5B, LRIG3, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NUTM1, PTPRK, RET, ROS1, RSPO3, SDC4, SLC34A2, SLC3A2, SQSTM1, TACC3, TPM3, TPR, TRIM33, WHSC1L1
Lymphoma
Acute Lymphoblastic Lymphomas
BCL11B, CREBBP (CBP), EBF1, KMT2A, MLLT10, MYC, P2RY8, PRDM16, STIL
Anaplastic Large Cell Lymphomas
ADGRG7, ALK, ATIC, CLTC, MSN, MYC, NPM1, TFG, TPM3, TPM4
Angioimmunoblastic T Cell Lymphomas
CD28, CTLA4, FIP1L1, PDGFRA
Burkitt Lymphomas
BCL6, MYC, PBX1, TCF3
Diffuse Large B Cell Lymphomas (DLBCL)
ALK, BCL11A, BCL6, CCND3, CIITA, CLTC, IGLL5, LPP, MAPK13 (p38delta), MYC, NPM1, PIM1, REL, SQSTM1, TBL1XR1, TOMM40, TP63, ZCCHC7
Follicular Lymphomas
AFF3, BCL2, BCL6, CIITA, MYC, TBL1XR1, TP63
Granulocytic Sarcomas
RUNX1 (AML1), RUNX1T1
Hodgkin Lymphomas
ALK, CIITA, JAK2, NPM1, SEC31A
Inflammatory Myofibroblastic Tumors
ALK, CARS, DCTN1
Lymphoblastic Lymphomas
BCR, CRLF2 (TSLPR), EPOR, ETV6, FGFR1, NOTCH1, PBX1, PDGFRB, RARA, TERT, ZCCHC7
Lymphoblastic T Cell Lymphomas
BCR, ETV6, FGFR1, FIP1L1, LYN, PDGFRA
Mantle Cell Lymphomas
CCND3, MYC
Mediastinal Large B Cell Lymphomas (MLBL)
CIITA, PDCD1LG2
Mediastinal Large B-Cell Lymphomas
CIITA, PDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL6, BIRC3 (c-IAP2), CCND3, MALT1, MYC
Peripheral T Cell Lymphomas
ALK, ETV6, FGFR3, IKZF2, ITK, MYO1F, NPM1, S100A7, SYK, TBL1XR1, THAP4, TP63, VAV1
Precursor T Cell Lymphoblastic Lymphomas
ABL1, JAK2, NUP214, PCM1, SET
T Cell Lymphomas
ATXN2L, BCL11B, FGFR1, IKZF2, JAK2
Other Lymphomas
ALK, ATXN2L, BCL6, BIRC3 (c-IAP2), CBFB, CCND1, CCND3, CDK6, CHIC2, CLTC, DEK, DUSP22, EIF4A1, JAK2, KMT2A, MALT1, MKL1, MLF1, MLLT10, MYC, NFKB2, NPM1, PICALM, PRDM16
Myelodysplastic Syndromes (MDS)
ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, DIAPH2, ERG, ETV6, FGFR1, FRYL, FUS, GOT1, HOXA11, HOXA13, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, MYH11, NDE1, NPM1, NUP214, NUP98, PAN3, PCM1, PDGFRB, PRDM16, PSMA2, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, SEPT9, SYK, TOP1, ZMYM2
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, CNTRL, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, FOXP1, HOXA9, HOXD13, JAK2, KANK1, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PCM1, PDGFRA, PDGFRB, PRKG2, PSIP1, RARA, RUNX1 (AML1), TNIP1
Ovarian Cancer
Carcinomas
ESRRA
Serous Cyst Adenocarcinomas
AKT2, AXL, FGR, INSR, JAK1
Pancreatic Cancer
Acinar Cell Carcinomas
GATM, HACL1, HERPUD1, SND1, ZSCAN30
Adenocarcinomas
ACSL3, ACVR2A, AKT3, BRAF, CANT1, DDX5, ELK4, ERG, ESRP1, ETV1, ETV4, ETV5, HNRNPA2B1, KLK2 (hGK-1, hK2), KRAS, NDRG1, PIK3CA (p110-alpha), RAF1, SLC45A3, TBL1XR1, TMPRSS2, UBE2L3
Carcinomas
BRAF, RAF1
Prostate Cancer
Adenocarcinomas
ACSL3, ACVR2A, AKT3, BRAF, CANT1, DDX5, ELK4, ERG, ESRP1, ETV1, ETV4, ETV5, HNRNPA2B1, KLK2 (hGK-1, hK2), KRAS, NDRG1, PIK3CA (p110-alpha), RAF1, SLC45A3, TBL1XR1, TMPRSS2, UBE2L3
Glandular Intraepithelial Neoplasia
ERG, TMPRSS2
Other Carcinomas
ERG, ETV1, TMPRSS2
Salivary Gland Cancer
Adenomas
FGFR1, PLAG1
Mucoepidermoid Carcinomas
CRTC1, MAML2
Warthin Tumors
CRTC1, MAML2
Other Carcinomas
ETV6, NTRK3
Other Salivary Gland Cancers
MYB
Sarcoma
Alveolar Soft Part Sarcomas
ASPSCR1, TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas
CAMTA1, CEP85L, CIC, LEUTX, ROS1, TFE3, YAP1
Askins Tumors
ERG, EWSR1, FLI1, FUS
Chondrosarcomas
ACVR2A, CDX1, EWSR1, FN1, HEY1, IRF2BP2, NCOA2, NR4A3 (NOR1), TAF15, TCF12, TFG
Clear Cell Sarcomas
ATF1, CREB1, EWSR1, FLI1, NUTM2B, YWHAE
Congenital (Infantile) Fibrosarcomas
ETV6, MET, NTRK3, TFG
Dermatofibrosarcoma Protuberans
COL1A1, PDGFB
Dermatofibrosarcomas Protuberans
COL1A1, PDGFB
Desmoplastic Small Round Cell Tumors
ERG, EWSR1, FLI1, PATZ1, WT1
Endometrial Stromal Sarcomas
ALK, BCOR, CXorf67, EPC1, FN1, JAZF1, MBTD1, MEAF6, NUTM2A, NUTM2B, PHF1, SUZ12, YWHAE, ZC3H7B
Epithelioid Sarcomas
CREB3L1, CREB3L2, EWSR1, FUS, KLF17, SS18, SSX1
Ewing's Sarcomas
CIC, ERG, ETV1, ETV4, EWSR1, FEV, FLI1, FOXO4, FUS, NFATC2, SMARCA5, SP3
Fibrosarcomas
BRAF, COL1A1, CREB3L1, CREB3L2, EWSR1, FUS, LMNA, NTRK1, PDGFB, TOM1L2
Leiomyosarcomas
EWSR1, HMGA2, PBX3, WT1
Liposarcomas
DDIT3 (GADD153, CHOP), EWSR1, FUS, HMGA2, LGR5, NUP107, TERT
Myofibroblastic Sarcomas
ALK, LMNA, NTRK1, RELA, ROS1, SRF, TFG, TPM3, YWHAE
Myxofibrosarcomas
CREB3L1, CREB3L2, FUS
Myxoid Chondrosarcomas
NR4A3 (NOR1), TAF15
Perivascular Epithelioid Cell Tumors (PEComa)
DVL2, SFPQ, TFE3
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)
CITED2, MED12, PRDM10
Rhabdoid Tumors
NCOA4, RET
Rhabdomyosarcomas
CITED2, EWSR1, FLI1, FOXO1, NCOA1, NCOA2, PAX3, PAX7, SRF, TEAD1, VGLL2
Small Round Cell Tumors
ERG, ETV1, EWSR1, FEV, FLI1, FOXO1, PAX3
Solitary Fibrous Tumors
NAB2, STAT6
Synovial Sarcomas
COL6A3, CSF1 (MCSF), S100A10, SS18, SS18L1, SSX1, SSX2, SSX2B, SSX4B
Undifferentiated; Unclassified or Other Sarcomas
ATF1, BCOR, BRD4, CCNB3, CREM, ERG, ETV4, EWSR1, FGF1, FGFR1, FLI1, FN1, FOXO1, FUS, GLI1, JAZF1, MAML3, MKL2, NPM1, NUTM1, PAX3, PLAG1, POU5F1 (OCT4), RUNX1 (AML1), RUNX1T1, SUZ12, USP6
Skin Cancer
Adnexal Tumors; Hidradenomas
CRTC1, MAML2
Atypical Spitzoid Tumors
ALK, TPM3
Benign Melanocytic Nevus
ALK, BRAF, CEP89, ERC1, FCHSD1, GOLGA5, KIF5B, LSM14A, MYO5A, PPFIBP1, PWWP2A, RET, ROS1, TPM3
Melanomas
AGK, ATF1, BRAF, CREB1, EWSR1, FCHSD1, FGR, PAPSS1, TRIM24
Spitzoid Melanomas
CEP89, LSM14A, MYO5A, PPFIBP1, PWWP2A
Soft Tissue Cancer
Clear Cell Sarcomas
ATF1, EWSR1
Congenital (Infantile) Fibrosarcomas
ETV6, NTRK3
Desmoplastic Small Round Cell Tumors
ERG, EWSR1, SSX1
Endometrial Stromal Sarcomas
ALK, FN1
Epithelioid Sarcomas
SS18
Inflammatory Myofibroblastic Tumors
ALK, ATIC, CARS, CLTC, DCTN1, PPFIBP1, RANBP2, SEC31A, TPM3, TPM4
Leiomyosarcomas
EWSR1, WT1
Liposarcomas; Myxoid-Round Cell
DDIT3 (GADD153, CHOP), EWSR1
Liposarcomas; Pleomorphic
DDIT3 (GADD153, CHOP), FUS
Rhabdoid Tumors
NCOA4, RET
Rhabdomyosarcomas
FOXO1, PAX3, PAX7
Sarcomas
ETV4, EWSR1
Small Round Cell Tumors
ETV1, EWSR1, FEV, FLI1
Solitary Fibrous Tumors
NAB2, STAT6
Synovial Sarcomas
SS18, SSX2, SSX2B
Other Fibrosarcomas
COL1A1, PDGFB
Stomach Cancer
Adenocarcinomas
AKT1, ERBB2 (HER-2, NEU), INSR
Thyroid Cancer
Adenoma-Nodule-Goitre
CCDC6, NCOA4, PAX8, PPARG, PRKAR1A, RET
Anaplastic Carcinomas
ALK, CCDC6, NCOA4, RET, STRN
Follicular Carcinomas
PAX8, PPARG
Hurthle Cell Carcinomas
CCDC6, NCOA4, RET
Mucoepidermoid Carcinomas
CRTC1, MAML2
Papillary Carcinomas
AGK, AKAP9, ALK, BRAF, CCDC6, EML4, ERC1, ETV6, GOLGA5, HOOK3, KTN1, NCOA4, NTRK1, NTRK3, PAX8, PCM1, PPARG, PRKAR1A, RET, STRN, TFG, TPM3, TRIM24, TRIM27, TRIM33
Urinary Tract Cancer
Endometrial Carcinomas
INSR, PIK3CA (p110-alpha)
Transitional Cell Carcinomas
BAIAP2L1, FGFR3, TACC3
Uterine Cancer
Endometrial Carcinomas
INSR, PIK3CA (p110-alpha)
Other Hematological Malignancies
Eosinophilia
ETV6, FOXP1, LYN, PDGFRA
Langerhans Cell Histiocytosis
NTRK3, PLEKHA6
Plasma Cell Myelomas
ABL1, BCR
Polycythemia Vera
GTF2H3
Severe Thrombocythemia
KANK1, PDGFRB
Other Myeloid Neoplasms
KLF2, PTK2B (PYK2), SEMA6A
Other Solid Tumors
Midline Carcinomas
BRD3, BRD4, NUTM1, WHSC1L1
Squamous Cell Carcinomas (SCC)
MAST2
Other Solid Tumors
ARHGAP26, BRD3, INSR, MAST2, MSMB, MUSK, NUMBL, NUTM1, PDGFRB, RSPO2, THADA
Other Cancers
Midline Carcinomas
BRD3, BRD4, NUTM1, WHSC1L1
Squamous Cell Carcinomas (SCC)
MAST2
Other Cancers
JAK3
Commercial Control Samples
ALK, BAIAP2L1, BRAF, CCDC6, CD74, EGFR (ERBB1), EML4, ERG, ETV6, FGFR3, KIF5B, LMNA, MET, NCOA4, NTRK1, NTRK3, PAX8, PPARG, RET, ROS1, SEPT14, SLC34A2, SLC45A3, TACC3, TFG, TMPRSS2, TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells
CD200, CD274 (PD-L1), CD274 (PD-L1), CD48, CD80, CD86, ITGAV, ITGB3, LGALS9, MICA, MICB, PDCD1LG2, TNFRSF14, VSIR
Stimulatory on Tumor Cells
CD40 (TNFRSF5), CD40LG, CD48, CD70, CD86, ICOSLG, TNFRSF9, TNFSF14, TNFSF4 (OX40L), TNFSF9
Inhibitory on T Cells
BTLA, CD160, CD200R1, CD244, CD274 (PD-L1), CD274 (PD-L1), CD28, CTLA4, HAVCR2, KLRC1, LAG3, LILRB1, LILRB3, PDCD1 (PD1), PDCD1 (PD1), VSIR
Stimulatory on T Cells
CD244, CD27 (TNFRSF7), CD28, CD40 (TNFRSF5), CD40LG, ICOS, TNFRSF14, TNFRSF18, TNFRSF4 (OX40), TNFRSF9, TNFSF14, TNFSF9
T Cell Receptor Genes
CD247, CD3D, CD3E, CD3G, TRAC, TRGC2
Major Histocompatibility Complex I Genes
B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HLA-H, MR1
Major Histocompatibility Complex II Genes
CD74, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5, IFI30
Other Checkpoint Molecules
ADORA2A, BTNL2, CD160, CD276, CD44, CD52, CD8A, HHLA2, IDO1 (IDO), IDO1 (IDO), IDO2, KIR3DL1, KLRD1, LAIR1, MS4A1, NRP1, TIGIT, TMIGD2, TNFRSF25 (DR3), TNFRSF8, TNFSF15, VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLA, CD274 (PD-L1), CD274 (PD-L1), CD80, CD8A, CSF2 (GM-CSF), CXCL11 (I-TAC, IP-9), HAVCR2, HLA-DRA, HLA-DRB1, HLA-DRB5, ICOS, IFNG, LAG3, PDCD1 (PD1), PDCD1 (PD1), PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2 (HER-2, NEU), FAS, IL5RA (CD125), INHBA, TNFRSF8, TNFSF4 (OX40L), TNFSF9
Immuno Stimulatory Gene Signature
CD160, CD19, CD200, CD27 (TNFRSF7), CD44, CTLA4, HLA-A, IL12RB2, IL17A, KIT (CD117), TNFRSF17
Immuno Suppressive Gene Signature
CD274 (PD-L1), CD274 (PD-L1), CD276, HAVCR2, PDCD1LG2, TGFB1
Upregulated in Cancer Vaccination Response
CCL5 (RANTES), CD3D, CD86, CD8A, CXCL10 (INP10), CXCL9 (MIG), GBP1, ICOS, IRF1, KLRD1, PSMB9, STAT1
Immune Cell Markers
CD8 T Cells
CD8A, CD8B, FLT3LG, GZMM, PRF1
Th1 Cells
CCL4 (MIP-1B), CD38, CD70, CSF2 (GM-CSF), CTLA4, DPP4, IFNG, IL12RB2, LTA (TNFB), STAT4, TBX21
Th17 Cells
IL17A, IL17RA, RORC
Th2 Cells
CXCR6, GATA3, IL26, LAIR2, MAF, PMCH, SMAD2 (MADH2), STAT6
Follicular Helper T Cells
BCL6, CXCL13, MAF, PDCD1 (PD1), PDCD1 (PD1)
Other T Helper Cell Markers
ANP32B, BATF, CD28, ICOS, NUP107
Regulatory T Cells
FOXP3
Gamma Delta T Cells
CD160, FEZ1, TRGC1
Central Memory T Cells
ATM, DOCK9, FYB1, NEFL, REPS1, TXK, USP9Y
Effector Memory T Cells
AKT3, CCR2, EWSR1, IL15RA, LTK, NFATC4 (NFAT3)
Other T Cell Markers
CD2, CD247, CD3D, CD3E, CD3G, CD6, IL2RB, TNFRSF25 (DR3), TRAC, TRGC2
Myeloid Derived Suppressor Cells
TGFB1
Cytotoxic Lymphocytes
CD3E, CD3G, CD8A, CD8B, EOMES, GZMA, GZMB, IFNG, KLRC1, KLRD1, NKG7, TBX21
Natural Killer Cells
BCL2, CD160, FOXJ1, FUT5, GTF3C1, GZMB, IL21R, KIR3DL1, MPPED1, NCR1, PLA2G6, RRAD, ZNF205
Activated Dendritic Cells
CCL1 (I-309), EBI3, LAMP3, OAS3
Immature Dendritic Cells
CD1A, CD1B, CD1E, F13A1, SYT17
Myeloid Dendritic Cells
CD1A, CD1B, CD1E
Plasmacytoid Dendritic Cells
IL3RA
Other Dendritic Cell Markers
CCL13 (MCP-4), CCL17 (TARC), CCL22 (MDC), CD209, HSD11B1
Macrophages
APOE, CCL7 (MCP-3), CD68, CHIT1, CXCL5 (ENA-78, LIX), MARCO, MSR1
Neutrophils
CSF3R (GM-CSFR), FPR2, MME
Eosinophils
CCR3, IL5RA (CD125), PTGDR2 (CRTH2, GPR44), SMPD3, THBS1 (TSP-1)
Mast Cells
CMA1, CTSG, KIT (CD117), MS4A2, PRG2, TPSAB1
B Cells
BANK1, BLK, CD19, CD79A, CR2, HLA-DOB, HLA-DQA1, MS4A1, PAX5, TNFRSF17
Antigen Presenting Cells
CMKLR1
Regulatory T Cell Gene Signature
CD274 (PD-L1), CD274 (PD-L1), JAK1, PDCD1LG2, TIGIT, TNFRSF18, TNFRSF4 (OX40), TNFRSF8, TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors
CCL5 (RANTES), CX3CL1, CXCL10 (INP10), CXCL9 (MIG), ITGB2, SELL (LECAM-1)
Other T Cell Trafficking & Infiltration into Tumors Genes
CCL17 (TARC), CCL4 (MIP-1B), CCR3, CCR6, CD274 (PD-L1), CD274 (PD-L1), CD44, CSF2 (GM-CSF), CXCL11 (I-TAC, IP-9), CXCL13, FOXP3, IFNG, ITGA4 (CD49D), ITGB7, LTA (TNFB), PDCD1 (PD1), PDCD1 (PD1), PDCD1LG2, PTEN, TNFRSF25 (DR3), TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion
CCL5 (RANTES), CD200, CD27 (TNFRSF7), CD69, CTLA4, CXCL10 (INP10), CXCL13, GBP1, HLA-DMA, HLA-DQA1, ICOS, IFI16, IFNG, ITGAV, TAP1 (ABCB2), TIGIT, TNFRSF9
Downregulated in T Cell Exhaustion
TNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes
BATF, TBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers
APP, CAPZB, CCL4 (MIP-1B), CCL5 (RANTES), CD8A, CSNK1E, CTLA4, CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL9 (MIG), EBI3, EHD1, GBA2, GZMB, HLA-DQA1, IDO1 (IDO), IDO1 (IDO), IFNG, INHBA, IRF2, NKG7, ODF2, PHKG2, PPIF, PRF1, SERPINA3, SHMT2, SIGMAR1, SMAD3 (MADH3), TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers
ACTG1, BNIP3L, CX3CL1, FOXN3, IFI27, JAK1, LTA4H, NAIP, OPTN, PRRC2B, PTEN, RBL2, TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers
ADAM28, AKNA, AOAH, ARHGAP9, CACNA2D2, CARD11, CARD16, CD109, CLEC11A, CORO1A, CORO1B, CXCR4, FLT3, FMNL1, HIVEP1, HIVEP2, IFI44L, IFITM1 (9-27), IGHA1, IGHM, IGSF6, IKZF1, ITPKA, LSM4, LST1, MAP3K14, NFAM1, NFKBIL1, PLA2G2D, POU2AF1 (OCA-B), PTPRCAP, SERPINB9, SH3BP5, SYTL1, TMC8, TNFRSF13B, TNFRSF19, ZFYVE9
Expression Correlates with Positive Objective Response Rates
CD274 (PD-L1), CD274 (PD-L1), CD276, CTLA4, HAVCR2, IDO1 (IDO), IDO1 (IDO), LAG3, PDCD1LG2, VTCN1
Upregulated during Treatment
CD8A, CTLA4, CXCL10 (INP10), EOMES, GZMA, GZMB, ICOS, IFNG, PRF1
Regulated during Treatment
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response
ADAM17 (CD156B), MYC, RHOC, TIMP1
Other Pre-Treatment Response Predictors
CDK2, CDKN2A (P16INK4A), LARGE1, NAB2, NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing
BTLA, CD274 (PD-L1), CD274 (PD-L1), CD80, HAVCR2, IDO1 (IDO), IDO1 (IDO), IDO2, LAG3, MICA, MICB, PDCD1 (PD1), PDCD1 (PD1), TGFB1, VSIR, VTCN1
Stimulates Cancer Cell Killing
IFNG
Antigen Processing & Presentation
Proteasome
PSMB10, PSMB9
Proteases
IFI30
Endoplasmic Reticulum & Lysosomal Transport
TAP1 (ABCB2), TAP2 (ABCB3), TAPBPL
Major Histocompatibility Complex I Genes
B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HLA-H, MR1
Major Histocompatibility Complex II Genes
CD74, HLA-DMA, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, IFI30
Immune Cell Receptors & Co-Receptors
CD8A, CD8B, KIR3DL1, KLRC1, KLRD1
Stimulates Antigen Presentation
CD40 (TNFRSF5), CD40LG
Interferon Gamma Response
Cytokines & Chemokines
CCL5 (RANTES), IL15RA, STAT1
Major Histocompatibility Complex I Genes
B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HLA-H
Major Histocompatibility Complex II Genes
HLA-DMA, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, IFI30
RNA Degradation
OAS3
Transcription Factors
IRF1, IRF2
Other Interferon Gamma Response Genes
CD44, GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons
CCL4 (MIP-1B), CCL5 (RANTES), CXCL10 (INP10)
Oncogenes
ABL1, AKT1, ALK, AR, BCL2, BRAF, CBL, CTNNB1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), EZH2, FGFR2, FGFR3, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3-3A, H3C2, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KIT (CD117), KRAS, MAP2K1, MED12, MET, MPL, MYD88, NFE2L2, NRAS, PDGFRA, PIK3CA (p110-alpha), PPP2R1A, PTPN11, RET, SETBP1, SF3B1, SMO, SPOP, SRC, SRSF2, TSHR, U2AF1
Tumor Suppressor Genes
ACVR1B, AMER1, APC, ARID1A, ARID2, ASXL1, ATM, B2M, BCOR, CDKN2A (P16INK4A), CIC, CREBBP (CBP), DAXX, FBXW7, KMT2D, MLH1, NOTCH2, PAX5, PBRM1, PIK3R1 (p85-ALPHA), PTEN, RUNX1 (AML1), SMAD2 (MADH2), SMAD4 (MADH4), SMARCB1, STK11 (LKB1), WT1
Cell Adhesion Molecules
ABL1, APC, CSF3R (GM-CSFR), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), JAK2, PDGFRA, PTEN, PTPN11, RAC1, RET, RHOA, SRC
Angiogenesis
CTNNB1, ERBB2 (HER-2, NEU), FGFR2, GATA2, PIK3CA (p110-alpha), PLCG1, PTEN, RUNX1 (AML1)
Apoptosis
ABL1, APC, BCL2, BRAF, CBL, CTNNB1, DAXX, FLT3, FOXL2, HRAS, ID3, MYCN, PTEN, RAD21, RAF1, STK11 (LKB1), WT1
Cell Cycle
ABL1, AKT1, APC, CDKN2A (P16INK4A), CHEK2 (RAD53), CREBBP (CBP), CUX1, FBXW7, FGFR2, HRAS, ID3, MYC, PTEN, RAD21, RHOA, SMARCB1, STK11 (LKB1), XPO1
DNA Damage & Repair
ABL1, APC, ATM, CHEK2 (RAD53), MLH1, POLE, RAD21, STK11 (LKB1)
Epigenetics
ARID1A, ARID2, ASXL1, BCOR, DICER1, DNMT3A, EZH2, H3-3A, H3C2, KMT2D, NSD2, PBRM1, SETBP1, SMARCB1, SPOP
Hypoxia Signaling
CREBBP (CBP), EPAS1, SMAD4 (MADH4)
Immune Response
ALK, B2M, BTK, CBLB, CD79B, CREBBP (CBP), CXCR4, JAK1, JAK2, JAK3, MAP2K1, MAP2K2 (MEK2), MYD88, PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, PTPN11
Inflammatory Response
CXCR4, JAK2, MYD88
Metabolism
IDH1, IDH2
mRNA Splicing
SF3B1, SRSF2, U2AF1, ZRSR2
Signal Transduction
AKT & PI3 Kinase Signaling
AKT1, CBL, ERBB2 (HER-2, NEU), FLT3, JAK2, KIT (CD117), PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN
Fibroblast Growth Factor Signaling
AKT1, FGFR1, FGFR2, FGFR3, FGFR4, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, PTPN11, SRC
G-Protein Coupled Receptor Signaling
AKT1, GNA11, GNAQ, GNAS, SMO, TSHR
Hormone Receptors
AR, ESR1 (ERα)
JAK / STAT Signaling
JAK1, JAK2, JAK3, STAT3
MAP Kinase Signaling
MAP2K1, MAP2K2 (MEK2), MAPK1 (ERK2), NRAS, PPM1D, RAF1
Notch Signaling
FBXW7, GATA2, NOTCH2
Receptor Tyrosine Kinases
ALK, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, FGFR1, FGFR4, FLT3, KIT (CD117), PDGFRA, RET
TGFb Signaling
ACVR1B, SMAD2 (MADH2)
WNT Signaling
AMER1, APC, CTNNB1, MED12, PPP2R1A
Other Signal Transduction Genes
KRAS, MET, SMAD4 (MADH4)
Transcription Factors
AR, CIC, CUX1, ESR1 (ERα), FBXW7, FOXL2, GATA2, ID3, MYC, MYCN, NFE2L2, NKX2-1, PAX5, RUNX1 (AML1), WT1
Ubiquitination
BCOR, CBLB, DAXX
Unfolded Protein Response
NFE2L2
Other Cancer Related Genes
DNM2, MPL, PRSS1, TERT