Farp2 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Predicted to act upstream of or within Rac protein signal transduction; hair cycle process; and neuron remodeling. Predicted to be located in cytoplasm. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Farp2 |
| Official Name | FERM, ARH/RhoGEF and pleckstrin domain protein 2 [Source:RGD Symbol;Acc:1308003] |
| Ensembl ID | ENSRNOG00000018051 |
| Bio databases IDs | |
| Aliases | FERM, ARH/RhoGEF and pleckstrin domain protein 2 |
| Synonyms | AI465173, D030026M03Rik, FERM, ARH/RhoGEF and pleckstrin domain protein 2, FERM, RhoGEF and pleckstrin domain protein 2, FIR, FLJ31039, FRG, mKIAA0793, PLEKHC3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Farp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Pleckstrin homology-like domain
- RhoGEF domain
- FERM N-terminal domain
- FERM domain
- FERM adjacent (FA)
- RhoGEF
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- PH domain
- FERM domain B-lobe
- Dbl homology domain
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Farp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- gallstone
- insulin-dependent diabetes mellitus
- chronic lymphocytic leukemia
- dementia
- prostatic carcinoma
- prostate cancer
- vitiligo
- metabolic syndrome X
- melanoma
role in cell
- growth
- quantity
- formation
- differentiation
- adhesion
- number
- organization
- function
- length
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cytosol
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Farp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- Rac protein signal transduction
- cell adhesion
- hair cycle process
- neuron remodeling
- actin cytoskeleton organization
- podosome assembly
- regulation of integrin activation
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- cytoskeletal protein binding