Ssr4 Gene Summary [Rat]

Part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ssr4
Official Name
signal sequence receptor subunit 4 [Source:RGD Symbol;Acc:62034]
Ensembl ID
ENSRNOG00000053172
Bio databases IDs NCBI: 29435 Ensembl: ENSRNOG00000053172
Aliases signal sequence receptor subunit 4
Synonyms CDG1Y, SIGNAL SEQUENCE receptor delta, signal sequence receptor, delta, signal sequence receptor subunit 4, SIGNAL SEQUENCE receptor δ, signal sequence receptor, δ, SSR-delta, SSR-δ, translocon-associated protein delta, translocon-associated protein δ, Trap, TRAPD, TRAP-delta, TRAP-δ
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ssr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Translocon-associated protein, delta subunit precursor (TRAP-delta)

Pathways

Biological processes and signaling networks where the Ssr4 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • congenital disorder of glycosylation type 1y
regulated by
  • CGA
  • NEF
  • corticosteroid
  • cyclosporin A
  • tetraethylammonium
  • HSP90B1
  • 5-fluorouracil
  • RARB
  • HECW1
  • Jurkat E6.1 cells

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Ssr4 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • endomembrane system
  • endoplasmic reticulum
  • Sec61 translocon complex

Gene-Specific Assays for Results You Can Trust

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