ZNF185

ZNF185 Gene Summary

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

Details

Type
Protein Coding
Official Symbol
ZNF185
Official Name
zinc finger protein 185 with LIM domain [Source:HGNC Symbol;Acc:HGNC:12976]
Ensembl ID
ENSG00000147394
Bio databases IDs NCBI: 7739 Ensembl: ENSG00000147394
Aliases zinc finger protein 185 with LIM domain, sciellin like
Synonyms
P1,SCELL,Zfp185,zinc finger protein 185,zinc finger protein 185 with LIM domain
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • zinc ion binding
  • LIM is a small protein-protein interaction domain, containing two zinc fingers
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • ETNK2
  • HDAC6
  • ESR1
  • COPS5
  • APEX1
  • ACTBL2
  • SOX2
  • HSPA5
  • PRPF8
  • PTGES3L-AARSD1
disease
  • head and neck squamous cell carcinoma
  • head and neck squamous cell cancer
  • squamous cell cancer
  • age-related hearing loss
  • squamous-cell carcinoma
regulated by
  • decitabine
  • ERBB2
  • EFNA1
  • BAZ2A
  • 10E,12Z-octadecadienoic acid
  • BTK
  • THRB
  • MAGI1
  • THZ1
  • 3M-002
regulates
role in cell

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ZNF185 gene, providing context for its role in the cell.

CELLULAR COMPONENT

Where in the cell the gene product is active
  • cytoskeleton
  • focal adhesion
  • cytoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • zinc ion binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.