HDAC6 Gene Summary [Human]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HDAC6 |
| Official Name | histone deacetylase 6 [Source:HGNC Symbol;Acc:HGNC:14064] |
| Ensembl ID | ENSG00000094631 |
| Bio databases IDs | |
| Aliases | histone deacetylase 6, protein phosphatase 1, regulatory subunit 90 |
| Synonyms | CPBHM, HD6, Hdac5, histone deacetylase 6, JM21, KDAC6, LOC100911205, mHDA2, PPP1R90, Sfc6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDAC6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SE14 repeat domain
- transcription regulator
- deacetylase motif
- heat shock protein binding
- enzyme inhibitor activity
- transcription factor binding
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- Hdac domain
- protein deacetylase activity
- BUZ domain
- tau protein binding
- ATPase inhibitor activity
- alpha-tubulin binding
- histone deacetylase
- tubulin deacetylase
- beta-tubulin binding
- NZF domain
- ubiquitin protein ligase binding
- catalytic domain
- nucleic acid binding
- beta-catenin binding
- ubiquitin protein ligase activity
- enzyme binding
- histone deacetylase binding
- ubiquitin binding
- protein binding
- deacetylase
- sequence-specific DNA binding
- Arginase-like and histone-like hydrolases
- microtubule binding
- binding protein
- Zn-finger in ubiquitin-hydrolases and other protein
- double-stranded DNA binding
- zinc finger domain
- SMIR motif
Pathways
Biological processes and signaling networks where the HDAC6 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- weight gain
- plasma cell myeloma
- lymphoma
- enteropathy-associated T-cell lymphoma
- acute myeloid leukemia
- pulmonary vascular leak
- T-cell acute lymphoblastic lymphoma
role in cell
- activation
- recruitment
- density
- size
- expression in
- phosphorylation in
- activation in
- apoptosis
- production in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- aggresome
- microtubule cytoskeleton
- Cytoplasm
- intracellular space
- perinuclear region
- basal bodies
- centrosome
- microtubules
- midbody
- cytosol
- uropod
- caveolae
- nucleoplasm
- nuclear bodies
- neurites
- multivesicular bodies
- cell membrane leading edge
- mitotic spindle
- perikaryon
- axons
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDAC6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to growth factor stimulus
- actin filament organization
- intracellular protein transport
- regulation of androgen receptor signaling pathway
- positive regulation of cellular response to oxidative stress
- misfolded or incompletely synthesized protein catabolic process
- negative regulation of transcription, DNA-dependent
- cellular response to parathyroid hormone stimulus
- autophagy
- aggresome assembly
- peptidyl-lysine deacetylation
- regulation of establishment of protein localization
- positive regulation of synaptic transmission, glutamatergic
- polyubiquitinated misfolded protein transport
- positive regulation of peptidyl-serine phosphorylation
- cellular response to misfolded protein
- negative regulation of gene expression, epigenetic
- cilium morphogenesis
- negative regulation of microtubule depolymerization
- negative regulation of axon extension involved in axon guidance
- regulation of microtubule-based movement
- dendritic spine morphogenesis
- response to corticosterone stimulus
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- negative regulation of protein complex disassembly
- regulation of autophagy
- regulation of macroautophagy
- response to immobilization stress
- negative regulation of proteolysis
- cellular response to heat
- enucleation
- negative regulation of protein complex assembly
- cellular response to hydrogen peroxide
- positive regulation of epithelial cell migration
- positive regulation of dendrite morphogenesis
- macromolecular complex disassembly
- response to misfolded protein
- positive regulation of receptor activity
- protein polyubiquitination
- protein deacetylation
- collateral sprouting
- positive regulation of tubulin deacetylation
- regulation of fat cell differentiation
- tubulin deacetylation
- regulation of gene expression, epigenetic
- protein destabilization
- lysosome localization
- negative regulation of oxidoreductase activity
- regulation of protein stability
- response to amphetamine
- negative regulation of hydrogen peroxide metabolic process
- cellular response to topologically incorrect protein
- axon transport of mitochondrion
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- cell leading edge
- histone deacetylase complex
- multivesicular body
- perikaryon
- microtubule associated complex
- nucleoplasm
- microtubule
- dendrite
- nucleus
- caveola
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- inclusion body
- aggresome
- axon
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- histone deacetylase binding
- tubulin deacetylase activity
- polyubiquitin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- acetylspermidine deacetylase activity
- transcription factor binding
- alpha-tubulin binding
- beta-catenin binding
- microtubule binding
- transcription corepressor binding
- ubiquitin protein ligase binding
- protein binding
- actin binding
- ubiquitin binding
- histone deacetylase activity
- beta-tubulin binding
- tau protein binding
- Hsp90 protein binding
- dynein complex binding
- protein deacetylase activity
- misfolded protein binding
- enzyme binding