GRID1 Gene Summary [Human]
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | GRID1 |
| Official Name | glutamate ionotropic receptor delta type subunit 1 [Source:HGNC Symbol;Acc:HGNC:4575] |
| Ensembl ID | ENSG00000182771 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor delta type subunit 1 |
| Synonyms | Delta1 glutamate receptor, GluD1, GluD1-b, GluRdelta1, Glur δ 1, glutamate ionotropic receptor delta type subunit 1, glutamate ionotropic receptor δ type subunit 1, glutamate receptor, ionotropic, delta 1, glutamate receptor, ionotropic, δ 1, LOC103690098 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRID1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- extracellular ligand-gated ion channel
- protein binding
- identical protein binding
- ion channel
- GABA receptor
- neurotransmitter receptor
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the GRID1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- dental caries
- schizophrenia
- nonalcoholic fatty liver disease
- post-traumatic stress disorder
- bipolar disorder
- metabolic syndrome X
- anorexia nervosa
- non-insulin-dependent diabetes mellitus
- Barrett syndrome
regulated by
- topotecan
- TGF beta
- DNMT3A
role in cell
- quantity
- number
- degeneration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRID1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- regulation of postsynaptic membrane potential
- ion transmembrane transport
- regulation of synaptic transmission
- glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- glutamate receptor activity