CKAP4 Gene Summary [Human]
Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CKAP4 |
| Official Name | cytoskeleton associated protein 4 [Source:HGNC Symbol;Acc:HGNC:16991] |
| Ensembl ID | ENSG00000136026 |
| Bio databases IDs | |
| Aliases | cytoskeleton associated protein 4 |
| Synonyms | 5630400A09RIK, CLIMP-63, cytoskeleton-associated protein 4, ERGIC-63, Image:5322388, LOC728680, P63, VS38C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CKAP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ischemic stroke
- septic shock
role in cell
- expression in
- activation in
- sphere formation by
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- lipid droplets
- specific granule membrane
- endoplasmic reticulum lumen
- lysosome membrane
- nuclear speckles
- alveolar epithelial lamellar bodies
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CKAP4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- rough endoplasmic reticulum
- endoplasmic reticulum
- lamellar body
- plasma membrane
- endoplasmic reticulum membrane
- lipid particle
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoskeleton
- membrane
- azurophil granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding