Grid1 Gene Summary [Mouse]
Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including regulation of postsynapse organization; social behavior; and synaptic signaling via neuropeptide. Part of trans-synaptic protein complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and spinal cord. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grid1 |
| Official Name | glutamate receptor, ionotropic, delta 1 [Source:MGI Symbol;Acc:MGI:95812] |
| Ensembl ID | ENSMUSG00000041078 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, delta 1 |
| Synonyms | Delta1 glutamate receptor, GluD1, GluD1-b, GluRdelta1, Glur δ 1, glutamate ionotropic receptor delta type subunit 1, glutamate ionotropic receptor δ type subunit 1, glutamate receptor, ionotropic, delta 1, glutamate receptor, ionotropic, δ 1, LOC103690098 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grid1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- extracellular ligand-gated ion channel
- protein binding
- identical protein binding
- ion channel
- GABA receptor
- neurotransmitter receptor
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the Grid1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- topotecan
- TGF beta
- DNMT3A
disease
- major depression
- dental caries
- schizophrenia
- nonalcoholic fatty liver disease
- post-traumatic stress disorder
- bipolar disorder
- metabolic syndrome X
- anorexia nervosa
- non-insulin-dependent diabetes mellitus
- Barrett syndrome
role in cell
- quantity
- number
- degeneration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grid1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- regulation of postsynaptic membrane potential
- ion transmembrane transport
- regulation of synaptic transmission
- glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- glutamate receptor activity