MPP2 Gene Summary [Human]
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MPP2 |
| Official Name | membrane palmitoylated protein 2 [Source:HGNC Symbol;Acc:HGNC:7220] |
| Ensembl ID | ENSG00000108852 |
| Bio databases IDs | |
| Aliases | membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2, MAGUK p55 subfamily member 2, discs large, homolog 2 |
| Synonyms | D11Bwg0652e, DKFZp761D0712, DLG2, Dlgh2, MAGUK p55 scaffold protein 2, membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), Pals4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ domain
- PDZ-domain binding
- Src Homology 3 domain superfamily
- L27 domain
- kinase
- guanylate kinase
- NK
- guanylate kinase-like domain
- ion channel binding
- structural molecule
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- sensory neuropathy
- tinnitus
- colon adenocarcinoma
- Vogt-Koyanagi-Harada disease
- vascular leak syndrome
- metabolic syndrome X
- infection by HIV-1
role in cell
- expression in
- epithelial barrier function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cytoskeleton
- cell surface
- synaptic membrane
- dendritic spines
- synapse
- dendrites
- postsynaptic density
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- protein homooligomerization
- long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite membrane
- cell-cell junction
- cytoskeleton
- cytoplasm
- dendritic shaft
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding