CDH6

CDH6 Gene Summary

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

Details

Type
Protein Coding
Official Symbol
CDH6
Official Name
cadherin 6 [Source:HGNC Symbol;Acc:HGNC:1765]
Ensembl ID
ENSG00000113361
Bio databases IDs NCBI: 1004 Ensembl: ENSG00000113361
Aliases cadherin 6, K-Cadherin
Synonyms
CAD6,cadherin 6,KCAD,Kidney-cadherin
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin, Y-type LIR-motif
  • Cadherin repeat-like domain

Pathways

Biological processes and signaling networks where the CDH6 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CTNNB1
  • CDH18
  • alpha catenin
  • PSEN1
  • TRPV2
disease
  • fallopian tube cancer
  • insomnia
  • primary peritoneal cancer
  • platinum-resistant high-grade serous ovarian cancer
  • high grade endometrioid ovarian cancer
  • COVID-19
  • androgenic alopecia
  • pervasive developmental disorder
  • vascular dementia
  • metastatic colorectal cancer
regulated by
  • tretinoin
  • SMAD3
  • IGF1
  • GDF2
  • decitabine
  • CD276
  • EMX2
  • ALOX5
  • SNCA
  • ARPE-19 cells
regulates
role in cell
  • adhesion
  • innervation by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • cell junction
  • cell surface
  • cellular membrane
  • cell-cell contacts
  • nucleoplasm
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CDH6 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • Notch signaling pathway
  • cell-cell junction assembly
  • adherens junction organization
  • multicellular organismal development
  • cell morphogenesis
  • cell-cell adhesion mediated by cadherin
  • cell adhesion
  • homophilic cell adhesion
  • cell migration

CELLULAR COMPONENT

Where in the cell the gene product is active
  • adherens junction
  • cell junction
  • catenin complex
  • plasma membrane
  • nucleoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • cadherin binding
  • calcium ion binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.