Cdh6 Gene Summary [Rat]
Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in female gonad development. Predicted to be located in cell junction; nucleoplasm; and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction and glutamatergic synapse. Orthologous to human CDH6 (cadherin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh6 |
| Official Name | cadherin 6 [Source:RGD Symbol;Acc:2322] |
| Ensembl ID | ENSRNOG00000013535 |
| Bio databases IDs | |
| Aliases | cadherin 6 |
| Synonyms | CAD6, cadherin 6, KCAD, Kidney-cadherin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- Cadherin repeat-like domain
Pathways
Biological processes and signaling networks where the Cdh6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fallopian tube cancer
- insomnia
- primary peritoneal cancer
- platinum-resistant high-grade serous ovarian cancer
- high grade endometrioid ovarian cancer
- COVID-19
- androgenic alopecia
- pervasive developmental disorder
- vascular dementia
- metastatic colorectal cancer
role in cell
- adhesion
- innervation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- cell surface
- cellular membrane
- cell-cell contacts
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- Notch signaling pathway
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell morphogenesis
- cell-cell adhesion mediated by cadherin
- cell adhesion
- homophilic cell adhesion
- cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell junction
- catenin complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- calcium ion binding
- beta-catenin binding