CD276 Gene Summary [Human]
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | CD276 |
| Official Name | CD276 molecule [Source:HGNC Symbol;Acc:HGNC:19137] |
| Ensembl ID | ENSG00000103855 |
| Bio databases IDs | |
| Aliases | CD276 molecule |
| Synonyms | 6030411F23Rik, B7-H3, B7RP-2, CD276 antigen, CD276 molecule |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD276 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- hepatocellular carcinoma
- breast cancer
- organismal death
- HER2-positive breast cancer
- squamous cell cancer of the oral cavity
- colorectal cancer
- liver cancer
- epithelial cancer
role in cell
- expression in
- proliferation
- migration
- phosphorylation in
- activation
- production in
- growth
- cellular infiltration by
- differentiation
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD276 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interferon-gamma production
- T cell activation
- regulation of cytokine production
- positive regulation of T cell proliferation
- T cell receptor signaling pathway
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding