REG3A Gene Summary [Human]
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | REG3A |
| Official Name | regenerating family member 3 alpha [Source:HGNC Symbol;Acc:HGNC:8601] |
| Ensembl ID | ENSG00000172016 |
| Bio databases IDs | |
| Aliases | regenerating family member 3 alpha |
| Synonyms | AV063448, HIP, HIP/PAP, INGAP, PAP, PAP1, PAP2, PAP-H, PBCGF, REG3, regenerating family member 3 alpha, regenerating family member 3 α, REG-III, REGIIIbeta |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REG3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- hormone
- protein binding
- carbohydrate binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- intraepithelial neoplasia
- inflammatory disorder
regulates
- AKT
- insulin
- Ins1
role in cell
- cell death
- proliferation
- growth
- activation in
- differentiation
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REG3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte differentiation
- positive regulation of wound healing
- signal transduction
- negative regulation of inflammatory response
- positive regulation of cell proliferation
- response to wounding
- heterophilic cell-cell adhesion
- response to peptide hormone stimulus
- acute-phase response
- positive regulation of keratinocyte proliferation
- response to symbiotic bacterium
- positive regulation of detection of glucose
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- peptidoglycan binding
- identical protein binding
- protein binding
- signaling receptor activity
- carbohydrate binding
- hormone activity