KLHL22 Gene Summary [Human]
Enables 14-3-3 protein binding activity. Involved in several processes, including cellular protein metabolic process; cellular response to leucine; and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including cytosol; intercellular bridge; and microtubule cytoskeleton. Part of Cul3-RING ubiquitin ligase complex. Colocalizes with lysosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KLHL22 |
| Official Name | kelch like family member 22 [Source:HGNC Symbol;Acc:HGNC:25888] |
| Ensembl ID | ENSG00000099910 |
| Bio databases IDs | |
| Aliases | kelch like family member 22 |
| Synonyms | 2610318I18RIK, FLJ14360, KELCHL, kelch-like 22, kelch-like family member 22, RGD1306288 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- coronary artery disease
- retinopathy
- focal cortical dysplasia of Taylor
regulated by
- tetradecanoylphorbol acetate
- ionomycin
- 5-fluorouracil
- CD24
role in cell
- proliferation
- expression in
- accumulation in
- formation
- activation
- production in
- growth
- migration
- prometaphase
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- Nucleus
- centrosome
- lysosome
- cytoplasmic bridges
- cytosol
- polar microtubule
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- cellular response to amino acid stimulus
- negative regulation of type I interferon production
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of cell growth
- cellular response to leucine
- negative regulation of autophagy
- mitotic sister chromatid segregation
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- intercellular bridge
- centrosome
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- polar microtubule
- cytosol
- Cul3-RING ubiquitin ligase complex
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- 14-3-3 protein binding