Btbd11 Gene Summary [Rat]
Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within exploration behavior; glutamatergic synaptic transmission; and protein stabilization. Predicted to be located in glutamatergic synapse. Orthologous to human ABTB3 (ankyrin repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btbd11 |
| Official Name | BTB domain containing 11 [Source:RGD Symbol;Acc:1308647] |
| Ensembl ID | ENSRNOG00000005758 |
| Bio databases IDs | |
| Aliases | BTB domain containing 11 |
| Synonyms | 6330404E16RIK, ABTB2B, ankyrin repeat and BTB domain containing 3, BTBD11, FLJ33957 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Btbd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- Ankyrin repeats (many copies)
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Ankyrin repeats (3 copies)
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- PDZ-domain binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- coronary artery disease
- myocardial infarction
- diabetic nephropathy
- COVID-19
- metabolic syndrome X
- tinnitus
- organismal death
- human papilloma virus infection
- oral cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- glutaminergic synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Btbd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- protein stabilization
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein heterodimerization activity
- PDZ domain binding