Dlgap1 Gene Summary [Rat]
Enables protein domain specific binding activity. A structural constituent of postsynaptic density. Involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Located in postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlgap1 |
| Official Name | DLG associated protein 1 [Source:RGD Symbol;Acc:620223] |
| Ensembl ID | ENSRNOG00000016196 |
| Bio databases IDs | |
| Aliases | DLG associated protein 1 |
| Synonyms | 4933422O14RIK, 9630002F18, BB075781, D17Bwg0511e, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP-1-α, DAP-1-β, DLGAP1A, DLGAP1B, DLG associated protein 1, DLGP1, GKAP, GKAP/SAPAP, GKAP/SAPAP1, GKPA/SAPAP, LOC102724716, LOC245710, LOC284214, mKIAA4162, rGKAP, SAPAP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlgap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein domain specific binding
- protein binding
- structural molecule
- PDZ binding motif
- proline rich domain
- Guanylate-kinase-associated protein (GKAP) protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- dementia
- colorectal cancer
- COVID-19
- eczema
- rheumatoid arthritis
- idiopathic scoliosis
- hypertension
- abnormality of the integument
- spontaneous preterm birth
role in cell
- expression in
- assembly
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- postsynaptic membrane
- dendritic spines
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlgap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging