Tiam1 Gene Summary [Rat]
Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tiam1 |
| Official Name | TIAM Rac1 associated GEF 1 [Source:RGD Symbol;Acc:1307455] |
| Ensembl ID | ENSRNOG00000021569 |
| Bio databases IDs | |
| Aliases | TIAM Rac1 associated GEF 1 |
| Synonyms | D16Ium10, D16Ium10e, D3ZWV8, NEDLDS, T cell lymphoma invasion and metastasis 1, TIAM, TIAM Rac1 associated GEF 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tiam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- phospholipid binding
- ephrin receptor binding
- T-lymphoma invasion and metastasis CC-Ex domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- protein binding domain
- PEST domain
- microtubule binding
- GEF domain
- RhoGEF
- kinase binding
- Raf-like Ras-binding domain
- receptor tyrosine kinase binding
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Ras-binding domain
- PH domain
- adjacent domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Tiam1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- disorder of pregnancy
- metastasis
- pancreatic cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- Down syndrome
- neurodevelopmental disorder with language delay and seizures
- COVID-19
role in cell
- expression in
- production in
- proliferation
- phosphorylation in
- apoptosis
- formation
- differentiation
- activation in
- migration
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- kinocilia
- glutaminergic synapse
- axon component
- perisynaptic region
- somatodendritic region
- Nucleus
- Plasma Membrane
- centrosome
- microtubules
- intercellular junctions
- cell-cell contacts
- cytosol
- membrane ruffles
- dendritic spines
- growth cone
- neurites
- synapse
- anchoring junction
- membrane rafts
- perikaryon
- postsynaptic density
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tiam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- Rac protein signal transduction
- regulation of non-canonical Wnt receptor signaling pathway
- regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of dendritic spine morphogenesis
- positive regulation of protein binding
- macromolecular complex assembly
- small GTPase mediated signal transduction
- positive regulation of cell proliferation
- response to cocaine
- cardiac muscle hypertrophy
- positive regulation of epithelial to mesenchymal transition
- regulation of ERK1 and ERK2 cascade
- regulation of epithelial to mesenchymal transition
- positive regulation of axonogenesis
- regulation of small GTPase mediated signal transduction
- ephrin receptor signaling pathway
- protein localization in membrane
- Wnt receptor signaling pathway, planar cell polarity pathway
- cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- cell-cell junction
- axonal growth cone
- dendritic spine
- ruffle membrane
- cytosol
- synapse
- neuronal cell body
- main axon
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding
- receptor tyrosine kinase binding
- kinase binding
- microtubule binding