Card10 Gene Summary [Rat]
Predicted to be involved in several processes, including activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in immunodeficiency 89. Orthologous to human CARD10 (caspase recruitment domain family member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Card10 |
| Official Name | caspase recruitment domain family, member 10 [Source:RGD Symbol;Acc:1304949] |
| Ensembl ID | ENSRNOG00000008401 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family, member 10 |
| Synonyms | BIMP1, CARMA3, caspase recruitment domain family member 10, caspase recruitment domain family, member 10, IMD89 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Card10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEMO-binding domain
- Caspase recruitment domain
- Growth-arrest specific micro-tubule binding
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Death Domain Superfamily of protein-protein interaction domains
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Card10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- immunodeficiency 89 and autoimmunity
- androgenic alopecia
- primary open-angle glaucoma
- hepatic injury
- renal clear cell adenocarcinoma
- renal clear cell cancer
- tumorigenesis
- anencephaly
role in cell
- expression in
- phosphorylation in
- activation in
- migration
- proliferation
- cell cycle progression
- survival
- damage
- degradation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Card10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- macromolecular complex assembly
- activation of NF-kappaB-inducing kinase activity
- regulation of apoptotic process
- negative regulation of cell migration involved in sprouting angiogenesis
Cellular Component
Where in the cell the gene product is active
- CBM complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- CARD domain binding
- receptor signaling complex scaffold activity