Alkbh3 Gene Summary [Rat]
Predicted to enable DNA demethylase activity; ferrous iron binding activity; and mRNA N1-methyladenosine dioxygenase activity. Predicted to be involved in DNA alkylation repair; cell population proliferation; and negative regulation of cytoplasmic translation. Predicted to be located in cytosol. Predicted to be active in mitochondrion and nucleoplasm. Orthologous to human ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alkbh3 |
| Official Name | alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase [Source:RGD Symbol;Acc:1359731] |
| Ensembl ID | ENSRNOG00000021678 |
| Bio databases IDs | |
| Aliases | alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase |
| Synonyms | 1700108H04Rik, 1810020C19Rik, ABH3, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase, alkB homolog 3, α-ketoglutarate-dependent dioxygenase, DEPC-1, hABH3, mABH3, PCA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alkbh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- 2-oxoglutarate:oxygen oxidoreductase
- demethylase activity
- enzyme
- protein binding
- hydrolase
- 2OG-Fe(II) oxygenase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- preeclampsia
- metabolic syndrome X
- infection by HIV-1
role in cell
- proliferation
- expression in
- growth
- apoptosis
- survival
- invasion by
- glycolysis in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alkbh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- cell proliferation
- negative regulation of cytoplasmic translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- protein binding
- ferrous iron binding
- oxidative RNA demethylase activity
- oxidative DNA demethylase activity