Serpinb7 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in positive regulation of biosynthetic process and positive regulation of glomerular mesangial cell proliferation. Predicted to be active in extracellular space. Biomarker of nephritis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb7 |
| Official Name | serpin family B member 7 [Source:RGD Symbol;Acc:71063] |
| Ensembl ID | ENSRNOG00000002555 |
| Bio databases IDs | |
| Aliases | serpin family B member 7 |
| Synonyms | 4631416M05Rik, MEGSIN, ovalbumin, PPKN, serine (or cysteine) peptidase inhibitor, clade B, member 7, serpin family B member 7, TP55 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinb7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- Nagashima type palmoplantar keratoderma
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- asthma
- global developmental delay with intellectual disability
- respiratory disorder
- allergy
- allergic asthma
- epidermal hyperplasia
role in cell
- expression in
- proliferation
- quantity
- accumulation
- cellular infiltration by
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinb7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transforming growth factor beta1 production
- positive regulation of collagen biosynthetic process
- positive regulation of platelet-derived growth factor production
- negative regulation of endopeptidase activity
- positive regulation of glomerular mesangial cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity