Ran Gene Summary [Rat]
Enables several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Involved in cellular response to mineralocorticoid stimulus; hippocampus development; and spermatid development. Located in male germ cell nucleus; manchette; and sperm flagellum. Part of nuclear pore. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ran |
| Official Name | RAN, member RAS oncogene family [Source:RGD Symbol;Acc:620367] |
| Ensembl ID | ENSRNOG00000000938 |
| Bio databases IDs | |
| Aliases | RAN, member RAS oncogene family |
| Synonyms | ARA24, Gsp1, GTPase Ran, RANGTPASE, RAN, member RAS oncogene family, Rasl2-9, RAS-like, family 2, locus 9, TC4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ran often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- protein domain specific binding
- chromatin binding
- enzyme
- protein binding
- magnesium ion binding
- Ras subfamily of RAS small GTPases
- RNA binding
- GTP binding
- small GTP-binding protein domain
- binding protein
- GTPase domain
- GDP binding
- dynein intermediate chain binding
- ribonucleoprotein binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- nuclear export signal receptor
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Ran gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- neoplasia
- Hutchinson-Gilford progeria syndrome
- psoriasis
- organismal death
- Alzheimer disease
- Parkinson disease
- esophageal cancer
- lymphomagenesis
- lymphoma
role in cell
- cell viability
- proliferation
- binding in
- apoptosis
- survival
- quantity
- cell death
- formation
- growth
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- manchette
- centrosome
- centriole
- midbody
- cytosol
- nuclear pores
- nucleoplasm
- nucleoli
- nuclear envelope
- sperm tail
- recycling endosomes
- chromatin
- perikaryon
- apical processes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ran gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- positive regulation of protein import into nucleus
- snRNA import into nucleus
- spermatid development
- mitotic spindle organization
- GTP metabolic process
- hippocampus development
- pre-miRNA export from nucleus
- DNA metabolic process
- protein export from nucleus
- mitotic cell cycle
- cell division
- ribosomal small subunit export from nucleus
- ribosomal large subunit export from nucleus
- ribosomal subunit export from nucleus
- protein import into nucleus
- viral reproduction
- mitotic sister chromatid segregation
- cellular response to mineralocorticoid stimulus
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleolus
- RNA nuclear export complex
- manchette
- chromatin
- male germ cell nucleus
- nucleoplasm
- nuclear pore
- nuclear envelope
- nucleus
- extracellular vesicular exosome
- melanosome
- cytoplasm
- centriole
- membrane
- cytosol
- recycling endosome
- macromolecular complex
- midbody
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- chromatin binding
- dynein intermediate chain binding
- nuclear export signal receptor activity
- magnesium ion binding
- GTP binding
- protein binding
- RNA binding
- protein heterodimerization activity
- GTPase activity
- cadherin binding
- small monomeric GTPase activity
- GDP binding
- pre-miRNA binding