Atp5f1d Gene Summary [Rat]
Contributes to ATP hydrolysis activity. Involved in response to resveratrol. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Used to study obesity. Biomarker of colitis and myocardial infarction. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5f1d |
| Official Name | ATP synthase F1 subunit delta [Source:RGD Symbol;Acc:621372] |
| Ensembl ID | ENSRNOG00000014625 |
| Bio databases IDs | |
| Aliases | ATP synthase F1 subunit delta |
| Synonyms | 0610008F14RIK, 1500000I11Rik, ATP5D, Atpase D, ATPD, ATP Synthase F1 Delta, ATP synthase F1 subunit delta, ATP synthase F1 subunit δ, ATP Synthase F1 δ, F1F0 ATPase delta, F1F0 ATPase δ, LOC100910032, LOC687032, LOC690935, MC5DN5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5f1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- adenosine-tetraphosphatase
- binding protein
- mitochondrial ATP synthase delta subunit
- ATP synthase, F1 epsilon subunit (delta in mitochondria)
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATP synthase, Delta/Epsilon chain, beta-sandwich domain
- structural molecule
- ATPase
- transporter
- alternate F1F0 ATPase, F1 subunit epsilon
Pathways
Biological processes and signaling networks where the Atp5f1d gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- mitochondrial complex V deficiency nuclear type 5
- Waldenström macroglobulinemia
- mitochondrial disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- Huntington disease
- chronic obstructive pulmonary disease
role in cell
- binding in
- glycolysis in
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cristae-like membrane
- mitochondrial envelope
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5f1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial proton-transporting ATP synthase complex assembly
- response to copper ion
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ADP binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism