NDUFA10 Gene Summary [Human]
The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | NDUFA10 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A10 [Source:HGNC Symbol;Acc:HGNC:7684] |
| Ensembl ID | ENSG00000130414 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A10, complex I 42kDa subunit |
| Synonyms | 2900053E13Rik, CI-42k, CI-42KD, Complex I-42KD, LOC101927147, MC1DN22, Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, Nadh dehydrogenase [ubiquinone] 1 α subcomplex subunit 10, NADH:ubiquinone oxidoreductase subunit A10, ndufa10l |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDUFA10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NK
- NADH2 dehydrogenase
- enzyme
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the NDUFA10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- mitochondrial disorder
- nuclear type 22 mitochondrial complex I deficiency
- colorectal cancer
- insulin resistance
- Leigh syndrome
- gait disturbance
- hereditary disorder
- adult acute myeloid leukemia
- chromophobe renal cell carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDUFA10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial matrix
- cytoplasm
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity