GOLT1B Gene Summary [Human]
Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in endoplasmic reticulum. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | GOLT1B |
| Official Name | golgi transport 1B [Source:HGNC Symbol;Acc:HGNC:20175] |
| Ensembl ID | ENSG00000111711 |
| Bio databases IDs | |
| Aliases | golgi transport 1B |
| Synonyms | 2310061A22Rik, CGI-141, GCT1, GCT2, golgi transport 1B, GOT1, GOT1B, RGD1310691, YMR292W |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOLT1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Got1/Sft2-like family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- thyroid carcinoma
- epithelial thyroid cancer
- epithelial cancer
- lung squamous cell carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOLT1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- endoplasmic reticulum
- macromolecular complex
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding