WNT3A Gene Summary [Human]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | WNT3A |
| Official Name | Wnt family member 3A [Source:HGNC Symbol;Acc:HGNC:15983] |
| Ensembl ID | ENSG00000154342 |
| Bio databases IDs | |
| Aliases | Wnt family member 3A |
| Synonyms | vt, wingless-type MMTV integration site family, member 3A, Wnt family member 3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- receptor agonist activity
- protein domain specific binding
- protein binding
- receptor binding
- cytokine
- identical protein binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT3A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- cancer
- epithelial cancer
- osteoarthritis
- androgenic alopecia
- thermal hyperalgesia
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- mechanical hypersensitivity
role in cell
- cell death
- expression in
- activation
- apoptosis
- proliferation
- activation in
- survival
- phosphorylation in
- clustering in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- endosomal membrane
- synapse
- multivesicular bodies
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNT3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myoblast differentiation
- protein localization
- Wnt receptor signaling pathway involved in forebrain neuroblast division
- transcription from RNA polymerase II promoter
- axon guidance
- cardiac muscle cell fate commitment
- fat cell differentiation
- positive regulation of skeletal muscle tissue development
- skeletal muscle cell differentiation
- negative regulation of neuron projection development
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- heart looping
- platelet aggregation
- positive regulation of peptidyl-serine phosphorylation
- dorsal/ventral neural tube patterning
- regulation of synapse organization
- positive regulation of receptor internalization
- neuron differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- B cell proliferation
- negative regulation of axon extension involved in axon guidance
- positive regulation of cardiac muscle cell differentiation
- positive regulation of collateral sprouting in absence of injury
- positive regulation of gene expression
- inner ear morphogenesis
- regulation of synaptic transmission
- positive regulation of B cell proliferation
- negative regulation of neurogenesis
- signalosome assembly
- positive regulation of cell-cell adhesion mediated by cadherin
- cell proliferation
- regulation of microtubule cytoskeleton organization
- hemopoiesis
- positive regulation of cell proliferation
- positive regulation of mesodermal cell fate specification
- positive regulation of transcription from RNA polymerase II promoter
- heart development
- somatic stem cell division
- paraxial mesodermal cell fate commitment
- positive regulation of neural precursor cell proliferation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- cell proliferation in midbrain
- positive regulation of dermatome development
- axis elongation involved in somitogenesis
- spinal cord association neuron differentiation
- cell proliferation in forebrain
- negative regulation of fat cell differentiation
- hippocampus development
- mammary gland development
- cellular response to retinoic acid
- positive regulation of protein phosphorylation
- cell fate commitment
- extracellular matrix organization
- positive regulation of cytokine production
- positive regulation of hepatocyte proliferation
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- Golgi lumen
- extracellular region
- endocytic vesicle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- frizzled binding
- protein domain specific binding
- protein binding
- transcription coactivator activity
- receptor agonist activity
- cytokine activity
- receptor binding