HDAC1 Gene Summary [Human]
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HDAC1 |
| Official Name | histone deacetylase 1 [Source:HGNC Symbol;Acc:HGNC:4852] |
| Ensembl ID | ENSG00000116478 |
| Bio databases IDs | |
| Aliases | histone deacetylase 1 |
| Synonyms | GON-10, HD1, Hdac1-ps, histone deacetylase 1, KDAC1, LOC630524, MommeD5, RPD3, RPD3L1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDAC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- transcription co-repressor
- deacetylase motif
- transcription factor binding
- chromatin binding
- IXCXE motif
- enzyme
- LXCXE binding site
- protein deacetylase activity
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
- IACEE motif
- catalytic domain
- nucleic acid binding
- NF-kappaB binding
- nuclear localization sequence
- enzyme binding
- histone deacetylase binding
- protein domain specific binding
- p53 binding
- deacetylase
- protein binding
- sequence-specific DNA binding
- DNA binding
- Arginase-like and histone-like hydrolases
- binding protein
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the HDAC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- Ovarian Cancer Signaling
- p53 Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
- TGF-β Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection by Influenza A virus subtype H3N2
- Sézary syndrome
- T-cell non-Hodgkin disease
- recurrent cutaneous T-cell lymphoma
- persistent cutaneous T-cell lymphoma
- liver neoplasm
- liver neoplasia
- tumorigenesis
- severe acute respiratory syndrome
regulated by
- beta-estradiol
- isobutylmethylxanthine
- valproic acid
- insulin
- dexamethasone
- FSH
- troglitazone
- tetradecanoylphorbol acetate
- TGF
- benzo(a)pyrene
role in cell
- apoptosis
- phosphorylation in
- production in
- expression in
- formation
- cell viability
- proliferation
- migration
- cell death
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- pericentric heterochromatin
- perikaryon
- axons
- toroidal chromatin structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDAC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- regulation of cell fate specification
- endoderm development
- fungiform papilla formation
- positive regulation of cell proliferation
- hair follicle placode formation
- odontogenesis of dentin-containing tooth
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- positive regulation of oligodendrocyte differentiation
- methylation-dependent chromatin silencing
- negative regulation of androgen receptor signaling pathway
- embryonic digit morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle cell proliferation
- circadian regulation of gene expression
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- negative regulation of myotube differentiation
- negative regulation of intrinsic apoptotic signaling pathway
- oligodendrocyte differentiation
- negative regulation of gene expression, epigenetic
- neuron differentiation
- positive regulation of receptor activity
- cellular response to platelet-derived growth factor stimulus
- protein deacetylation
- hippocampus development
- eyelid development in camera-type eye
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- epidermal cell differentiation
- positive regulation of gene expression
- heterochromatin assembly
- negative regulation of apoptotic process
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- histone deacetylase complex
- neuronal cell body
- chromatin
- nucleoplasm
- heterochromatin
- nucleus
- cytoplasm
- transcriptional repressor complex
- NuRD complex
- cytosol
- macromolecular complex
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- histone deacetylase binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- nucleosomal DNA binding
- transcription corepressor binding
- core promoter sequence-specific DNA binding
- NF-kappaB binding
- p53 binding
- protein binding
- histone deacetylase activity
- transcription corepressor activity
- Krueppel-associated box domain binding
- protein deacetylase activity
- E-box binding
- enzyme binding