Ndufa10l1 Gene Summary [Rat]
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa10l1 |
| Official Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 [Source:RGD Symbol;Acc:1589745] |
| Ensembl ID | ENSRNOG00000016470 |
| Bio databases IDs | |
| Aliases | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 |
| Synonyms | 2900053E13Rik, CI-42k, CI-42KD, Complex I-42KD, LOC101927147, MC1DN22, Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, Nadh dehydrogenase [ubiquinone] 1 α subcomplex subunit 10, NADH:ubiquinone oxidoreductase subunit A10, ndufa10l |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufa10l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NK
- NADH2 dehydrogenase
- enzyme
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Ndufa10l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- mitochondrial disorder
- nuclear type 22 mitochondrial complex I deficiency
- colorectal cancer
- insulin resistance
- Leigh syndrome
- gait disturbance
- hereditary disorder
- adult acute myeloid leukemia
- chromophobe renal cell carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufa10l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial matrix
- cytoplasm
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity