Dock2 Gene Summary [Mouse]
Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock2 |
| Official Name | dedicator of cyto-kinesis 2 [Source:MGI Symbol;Acc:MGI:2149010] |
| Ensembl ID | ENSMUSG00000020143 |
| Bio databases IDs | |
| Aliases | dedicator of cyto-kinesis 2 |
| Synonyms | AABR07029272.1, CED-5, dedicator of cyto-kinesis 2, Hch, IMD40, LOC102557505, MBC, MYOBLAST CITY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- DHR-2, Lobe A
- T-cell receptor binding
- GTPase activator
- DOCK N-terminus
- protein binding
- Src Homology 3 domain superfamily
- GEF domain
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- guanyl-nucleotide exchange factor
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- habitual abortion
- ulcerative colitis
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- diabetic nephropathy
- immunodeficiency 40
- weight gain
- esophageal adenocarcinoma
- esophageal carcinoma formation
phenotypes
- decreased bone mineral density
- abnormal B cell differentiation
- abnormal CD4-positive T cell differentiation
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal CD8-positive alpha-beta T cell number
- abnormal CD8-positive alpha-beta cytotoxic T cell morphology
- abnormal Peyer's patch morphology
- abnormal T cell morphology
- abnormal bone mineral density
- abnormal cell migration
- abnormal class switch recombination
- abnormal hematopoietic system morphology/development
- abnormal humoral immune response
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal leukocyte migration
- abnormal lymphocyte morphology
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- decreased B cell number
- decreased B-1a cell number
- decreased B-1b cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased IgE level
- decreased IgG level
- decreased NK cell number
- decreased T cell number
- decreased lymphocyte cell number
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased response to antigen
- decreased single-positive T cell number
- impaired hematopoiesis
- impaired neutrophil chemotaxis
- increased B cell number
- increased B-1 B cell number
- increased CD8-positive alpha-beta T cell number
- increased IgE level
- increased NK cell number
- increased alpha-beta T cell number
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased macrophage cell number
- increased neutrophil cell number
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased single-positive T cell number
- lymph node hypoplasia
- spleen hypoplasia
role in cell
- chemotaxis
- formation
- migration
- quantity
- expression in
- production in
- adhesion
- activation in
- proliferation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- cortical rim
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- myoblast fusion
- alpha-beta T cell proliferation
- positive thymic T cell selection
- immunological synapse formation
- myeloid dendritic cell activation involved in immune response
- chemotaxis
- macropinocytosis
- membrane raft polarization
- regulation of small GTPase mediated signal transduction
- establishment of T cell polarity
- positive regulation of phagocytosis
- actin cytoskeleton organization
- cell migration
- negative thymic T cell selection
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- specific granule lumen
- cytoplasm
- membrane
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- T cell receptor binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding