Tnnt3 Gene Summary [Rat]
Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Involved in regulation of striated muscle contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnnt3 |
| Official Name | troponin T3, fast skeletal type [Source:RGD Symbol;Acc:3883] |
| Ensembl ID | ENSRNOG00000020332 |
| Bio databases IDs | |
| Aliases | troponin T3, fast skeletal type |
| Synonyms | AMCD2B, beta-TnTF, DA2B2, FAST SKELETAL TROPONIN T3, Fast tnt, fsTnT, fTnT, Tnt, TNTF, troponin T3, fast skeletal type, Troponin t3, skeletal fast, troponin T3, skeletal, fast, β-TnTF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnnt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Troponin
- cytoskeletal protein binding
- actin binding
- tropomyosin binding
- troponin C binding
- heptad repeat domain
Pathways
Biological processes and signaling networks where the Tnnt3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- distal arthrogryposis type 2B2
- breast carcinoma
- nemaline myopathy
- Duchenne muscular dystrophy
- diabetic nephropathy
- squamous-cell carcinoma
- squamous cell cancer
- papilloma
- papillomatosis
regulates
- HAMP
- ATPase
role in cell
- isometric tension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnnt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle contraction
- regulation of ATPase activity
- sarcomere organization
- regulation of striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytosol
- troponin complex
Molecular Function
What the gene product does at the molecular level
- actin binding
- troponin C binding
- calcium-dependent protein binding
- troponin I binding
- tropomyosin binding