Agrn Gene Summary [Rat]
Enables calcium ion binding activity; cytokine binding activity; and dystroglycan binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of plasma membrane bounded cell projection organization; and synapse organization. Acts upstream of or within receptor clustering. Located in axonal growth cone; basement membrane; and synapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agrn |
| Official Name | agrin [Source:RGD Symbol;Acc:2067] |
| Ensembl ID | ENSRNOG00000020205 |
| Bio databases IDs | |
| Aliases | agrin |
| Synonyms | AGR, AGRIN, CMS8, CMSPPD, LOC100503504, Neural agrin, nmf380 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- LamG
- factor I membrane attack complex
- SEA domain
- calcium ion binding
- protein binding
- TGFbeta binding
- KAZAL_FS
- glycosaminoglycan binding
- acetylcholine receptor regulator
- EGF_CA
- alpha dystroglycan binding domain
- Laminin-type epidermal growth factor-like domai
- binding protein
- structural constituent of cytoskeleton
- laminin binding
- ATPase inhibitor activity
- Agrin NtA domain
- ion channel binding
- receptor agonist activity
- laminin G domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Agrn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- metastasis
- neoplasia
- congenital myasthenic syndrome type 8
- Alzheimer disease
- sessile serrated lesion
- organismal death
- hyperopia
- pancreatic epithelial cancer
- non-insulin-dependent diabetes mellitus
role in cell
- formation
- activation in
- apoptosis
- expression in
- phosphorylation in
- quantity
- proliferation
- differentiation
- survival
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- glutaminergic synapse
- axon component
- extracellular vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- lysosomal compartment
- neuromuscular junctions
- myelin sheath
- synapse
- sarcolemma
- extracellular matrix
- basal lamina
- axons
- exosomes
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clustering of voltage-gated sodium channels
- neuromuscular junction development
- cytoskeleton organization
- synapse organization
- signal transduction
- positive regulation of filopodium assembly
- G-protein coupled acetylcholine receptor signaling pathway
- receptor clustering
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- positive regulation of synaptic growth at neuromuscular junction
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- lysosomal lumen
- synapse
- Golgi lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate binding
- protein binding
- calcium ion binding
- heparan sulfate proteoglycan binding
- sialic acid binding
- dystroglycan binding
- structural constituent of cytoskeleton
- laminin binding
- extracellular matrix structural constituent