ISG20 Gene Summary [Human]
Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ISG20 |
| Official Name | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] |
| Ensembl ID | ENSG00000172183 |
| Bio databases IDs | |
| Aliases | interferon stimulated exonuclease gene 20 |
| Synonyms | 1600023I01Rik, 2010107M23Rik, CD25, DnaQL, HEM45, HEM46, interferon stimulated exonuclease gene 20, Interferon Stimulated Gene 20kd, interferon-stimulated protein, IS320 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISG20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U1 snRNA binding
- U2 snRNA binding
- 3'-5' exoribonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- snoRNA binding
- enzyme
- single-stranded DNA specific 3'-5' exodeoxyribonuclease
Pathways
Biological processes and signaling networks where the ISG20 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin basal cell carcinoma
- basal cell skin cancer
- diabetes mellitus
- endometriosis
- limited systemic sclerosis
- psoriasis
- systemic lupus erythematosus nephritis
- diffuse cutaneous systemic sclerosis
- colon cancer
- diabetic nephropathy
role in cell
- cell death
- expression in
- production in
- proliferation
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear bodies
- Cajal bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISG20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA catabolic process
- innate immune response
- defense response to virus
- rRNA processing
- response to virus
- negative regulation of viral genome replication
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- Cajal body
- cytoplasmic mRNA processing body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- exoribonuclease II activity
- 3'-5'-exoribonuclease activity
- metal ion binding
- exonuclease activity
- U1 snRNA binding
- U3 snoRNA binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- U2 snRNA binding