GNAZ Gene Summary [Human]
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GNAZ |
| Official Name | G protein subunit alpha z [Source:HGNC Symbol;Acc:HGNC:4395] |
| Ensembl ID | ENSG00000128266 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha z |
| Synonyms | AI847979, G alpha Z, G protein subunit alpha z, G protein subunit α z, G-protein α z, guanine nucleotide binding protein, alpha z subunit, guanine nucleotide binding protein, α z subunit, GXA, Gz, gz-alpha, gz-α, G α Z, HG1H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNAZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- enzyme inhibitor activity
- G-protein-coupled receptor binding
- GTPase
- G-protein alpha subunit
- enzyme
- protein binding
- enzyme regulator activity
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNAZ gene in human plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- G Protein Signaling Mediated by Tubby
- G-Protein Coupled Receptor Signaling
- GABA Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- TEC Kinase Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- quantity
- chemotaxis
- aggregation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- nuclear envelope
- synaptic vesicles
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNAZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- negative regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- dendrite
- heterotrimeric G-protein complex
- cytoplasm
- cell body
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- protein binding
- metal ion binding
- GTPase activity
- adenylate cyclase inhibitor activity
- G-protein beta/gamma-subunit complex binding
- G-protein coupled serotonin receptor binding