Esd Gene Summary [Mouse]
Enables hydrolase activity, acting on ester bonds. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esd |
| Official Name | esterase D/formylglutathione hydrolase [Source:MGI Symbol;Acc:MGI:95421] |
| Ensembl ID | ENSMUSG00000021996 |
| Bio databases IDs | |
| Aliases | esterase D/formylglutathione hydrolase |
| Synonyms | Es-10, Esterase 10, Esterase D, esterase D/formylglutathione hydrolase, FGH, S-Formylglutathione Hydrolase, sid478 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-formylglutathione hydrolase
- Prolyl oligopeptidase family
- alpha/beta hydrolases
- Putative esterase
- enzyme
- protein binding
- identical protein binding
- carboxylesterase
- ester bond hydrolase
Pathways
Biological processes and signaling networks where the Esd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum lumen
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formaldehyde catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytoplasmic vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- methylumbelliferyl-acetate deacetylase activity
- hydrolase activity, acting on ester bonds
- S-formylglutathione hydrolase activity
- identical protein binding
- protein binding
- carboxylic ester hydrolase activity