Gnl2 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in peripheral nervous system ganglion; renal cortex; thymus primordium; and vibrissa. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnl2 |
| Official Name | guanine nucleotide binding protein-like 2 (nucleolar) [Source:MGI Symbol;Acc:MGI:2385207] |
| Ensembl ID | ENSMUSG00000028869 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein-like 2 (nucleolar) |
| Synonyms | G protein nucleolar 2, guanine nucleotide binding protein nucleolar 2, HUMAUANTIG, LOC633966, NGP1, Nog2, Nug2, RGD1305006 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NGP1NT (NUC091) domain
- ribosome biogenesis GTP-binding protein YlqF
- 50S ribosome-binding GTPase
- enzyme
- Circularly permuted YlqF-related GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
role in cell
- expression in
- activation in
- processing in
- binding in
- G1/S phase transition
- hyperphosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome biogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- nucleolus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- GTPase activity