Plin5 Gene Summary [Mouse]
Enables identical protein binding activity and lipase binding activity. Involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of triglyceride storage; and regulation of lipid metabolic process. Located in cytosol. Colocalizes with lipid droplet. Is expressed in brown fat. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plin5 |
| Official Name | perilipin 5 [Source:MGI Symbol;Acc:MGI:1914218] |
| Ensembl ID | ENSMUSG00000011305 |
| Bio databases IDs | |
| Aliases | perilipin 5 |
| Synonyms | 2310076L09Rik, LSDA5, LSDP5, MLDP, OXPAT, PAT-1, perilipin 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plin5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- protein binding
- identical protein binding
- Perilipin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- impaired glucose tolerance
- cardiac remodeling
- cardiac hypertrophy
- concentric hypertrophy of left ventricle
- hyperactive behavior
- osteoarthritis
role in cell
- expression in
- accumulation in
- formation
- formation in
- function
- recruitment
- organization
- utilization by
- accumulation
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- membrane surface
- Mitochondria
- lipid droplets
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plin5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- positive regulation of fatty acid beta-oxidation
- negative regulation of fatty acid beta-oxidation
- positive regulation of triglyceride biosynthetic process
- negative regulation of triglyceride catabolic process
- negative regulation of lipase activity
- lipid particle organization
- positive regulation of lipase activity
- mitochondrion localization
- positive regulation of lipid storage
- negative regulation of peroxisome proliferator activated receptor signaling pathway
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- lipase binding
- identical protein binding
- protein binding