Rasgrp1 Gene Summary [Mouse]
Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in activation of GTPase activity; positive regulation of T cell differentiation in thymus; and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including mast cell degranulation; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and vesicle transport along microtubule. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including brain and olfactory epithelium. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasgrp1 |
| Official Name | RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635] |
| Ensembl ID | ENSMUSG00000027347 |
| Bio databases IDs | |
| Aliases | RAS guanyl releasing protein 1 |
| Synonyms | CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP, RAS guanyl releasing protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rasgrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Ras exchanger motif
- RasGEF
- identical protein binding
- EF-hand domain
- diacylglycerol binding domain
- zinc ion binding
- EF hand
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1 domain (from RasGRP)
- REM
- phospholipid binding
- EF-hand, calcium binding motif
- lipid binding
- EF-hand domain pair
- nuclear localization sequence
- calcium ion binding
- EFh
- Cdc25 domain
- polybasic membrane localization signal
- suppressor of plasma membrane targeter domain
- binding protein
- diacylglycerol binding
- guanyl-nucleotide exchange factor
- zinc finger domain
Pathways
Biological processes and signaling networks where the Rasgrp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- insomnia
- non-insulin-dependent diabetes mellitus
- multiple sclerosis
- neoplasia
- squamous cell skin cancer
- squamous cell cancer
- epithelial cancer
- skin cancer
- epithelial neoplasia
role in cell
- apoptosis
- phosphorylation in
- activation
- function
- expression in
- activation in
- maturation
- adhesion
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rasgrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- secretory granule localization
- positive regulation of T cell differentiation in thymus
- T cell activation
- positive regulation of Ras protein signal transduction
- B cell activation
- mast cell degranulation
- positive regulation of GTPase activity
- positive regulation of natural killer cell differentiation
- positive regulation of granulocyte macrophage colony-stimulating factor production
- inflammatory response to antigenic stimulus
- positive regulation of interferon-gamma production
- vesicle transport along microtubule
- natural killer cell activation
- positive regulation of tumor necrosis factor production
- signal transduction
- B cell proliferation
- Ras protein signal transduction
- regulation of p38MAPK cascade
- positive regulation of natural killer cell mediated cytotoxicity
- regulation of ERK1 and ERK2 cascade
- regulation of protein kinase B signaling cascade
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- T cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- diacylglycerol binding
- lipid binding
- phosphatidylcholine binding