Gfi1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity. Involved in cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including inner ear development; mechanosensory behavior; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Is expressed in several structures, including aorta-gonad-mesonephros; cranial ganglion; gut epithelium; hemolymphoid system; and sensory organ. Used to study severe congenital neutropenia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; myelodysplastic syndrome; and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gfi1 |
| Official Name | growth factor independent 1 transcription repressor [Source:MGI Symbol;Acc:MGI:103170] |
| Ensembl ID | ENSMUSG00000029275 |
| Bio databases IDs | |
| Aliases | growth factor independent 1 transcription repressor |
| Synonyms | GFI1A, growth factor independent 1 transcriptional repressor, growth factor independent 1 transcription repressor, Pal-1, SCN2, ZNF163 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gfi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger DNA binding domain
- transcription regulator
- nucleic acid binding
- protein binding activity, bridging
- SNAG domain
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Gfi1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperactive behavior
- lymphomagenesis
- absent pinna reflex
- hearing loss
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- neutropenia
- adult nonimmune chronic idiopathic neutropenia
- androgenic alopecia
role in cell
- activation in
- apoptosis
- cell death
- expression in
- adhesion
- quantity
- differentiation
- function
- activation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gfi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of calcidiol 1-monooxygenase activity
- negative regulation of transcription, DNA-dependent
- cellular response to lipopolysaccharide
- negative regulation of neuron projection development
- negative regulation of NF-kappaB transcription factor activity
- regulation of toll-like receptor signaling pathway
- negative regulation of vitamin D biosynthetic process
- positive regulation of interleukin-6-mediated signaling pathway
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- transcriptional repressor complex
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription