RASGRP1 Gene Summary [Human]
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RASGRP1 |
| Official Name | RAS guanyl releasing protein 1 [Source:HGNC Symbol;Acc:HGNC:9878] |
| Ensembl ID | ENSG00000172575 |
| Bio databases IDs | |
| Aliases | RAS guanyl releasing protein 1, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II |
| Synonyms | CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP, RAS guanyl releasing protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASGRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Ras exchanger motif
- RasGEF
- identical protein binding
- EF-hand domain
- diacylglycerol binding domain
- zinc ion binding
- EF hand
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1 domain (from RasGRP)
- REM
- phospholipid binding
- EF-hand, calcium binding motif
- lipid binding
- EF-hand domain pair
- nuclear localization sequence
- calcium ion binding
- EFh
- Cdc25 domain
- polybasic membrane localization signal
- suppressor of plasma membrane targeter domain
- binding protein
- diacylglycerol binding
- guanyl-nucleotide exchange factor
- zinc finger domain
Pathways
Biological processes and signaling networks where the RASGRP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- insomnia
- non-insulin-dependent diabetes mellitus
- multiple sclerosis
- neoplasia
- squamous cell skin cancer
- squamous cell cancer
- epithelial cancer
- skin cancer
- epithelial neoplasia
role in cell
- apoptosis
- phosphorylation in
- activation
- function
- expression in
- activation in
- maturation
- adhesion
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASGRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- secretory granule localization
- positive regulation of T cell differentiation in thymus
- T cell activation
- positive regulation of Ras protein signal transduction
- B cell activation
- mast cell degranulation
- positive regulation of GTPase activity
- positive regulation of natural killer cell differentiation
- positive regulation of granulocyte macrophage colony-stimulating factor production
- inflammatory response to antigenic stimulus
- positive regulation of interferon-gamma production
- vesicle transport along microtubule
- natural killer cell activation
- positive regulation of tumor necrosis factor production
- signal transduction
- B cell proliferation
- Ras protein signal transduction
- regulation of p38MAPK cascade
- positive regulation of natural killer cell mediated cytotoxicity
- regulation of ERK1 and ERK2 cascade
- regulation of protein kinase B signaling cascade
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- T cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- diacylglycerol binding
- lipid binding
- phosphatidylcholine binding