Cd8b1 Gene Summary [Mouse]
Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Located in external side of plasma membrane. Part of receptor complex. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to several human genes including CD8B (CD8 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd8b1 |
| Official Name | CD8 antigen, beta chain 1 [Source:MGI Symbol;Acc:MGI:88347] |
| Ensembl ID | ENSMUSG00000053044 |
| Bio databases IDs | |
| Aliases | CD8 antigen, beta chain 1 |
| Synonyms | CD8B1, CD8beta, CD8 subunit beta, CD8 subunit beta 1, CD8 subunit β, CD8 subunit β 1, Cd8 β, LEU2, LOC100509003, LY3, Ly-C, LYT3, P37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd8b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- complementarity-determining region
- palmitoylation site
- Immunoglobulin V-Type
- immunoglobulin domain
- Cdr3 domain
- Immunoglobulin I-set domain
- protein binding
- beta strand or sheet
- cytoplasmic domain
- stalk region
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- cytosolic tail domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd8b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- progressive supranuclear palsy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- adenoid cystic carcinoma
role in cell
- activation
- number
- differentiation
- development
- function
- abnormal morphology
- cellular subpopulation ratio
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- endosomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd8b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- T cell activation
- transmembrane receptor protein tyrosine kinase signaling pathway
- adaptive immune response
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- T cell receptor complex
- receptor complex
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- MHC class I protein binding