Lck Gene Summary [Mouse]
Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lck |
| Official Name | lymphocyte protein tyrosine kinase [Source:MGI Symbol;Acc:MGI:96756] |
| Ensembl ID | ENSMUSG00000000409 |
| Bio databases IDs | |
| Aliases | lymphocyte protein tyrosine kinase |
| Synonyms | Hck-3, IMD22, Lck1, LCK proto-oncogene, Src family tyrosine kinase, Lcktkr, LSK, Lskt, lymphocyte protein tyrosine kinase, p56-LCK, pp58lck, YT16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lck often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- ATP-binding domain
- T-cell receptor binding
- protein-tyrosine kinase
- Protein kinase domain
- unique protein domain
- phospholipase activator
- identical protein binding
- activation loop
- myristoylation sequence
- CD8 receptor binding
- serine phosphorylation site
- Src homology 2 (SH2) domain
- SH1 domain
- Tyrosine kinase, catalytic domain
- membrane targeting signal
- SH4 domain
- palmitoylation site
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- SH2-domain binding
- lipid raft association site
- protein phosphatase binding
- enzyme binding
- Tyrosine autophosphorylation site
- antigen binding
- linker domain
- phosphotyrosine binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- CD4 receptor binding
- phosphorylation site
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- ATPase binding
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- tyrosine kinase domain
- modulatory domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Lck gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Calcium-induced T Lymphocyte Apoptosis
- CD28 Signaling in T Helper Cells
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin A Signaling
- G Protein Signaling Mediated by Tubby
- HER-2 Signaling in Breast Cancer
- iCOS-iCOSL Signaling in T Helper Cells
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- IL-2 Signaling
- Natural Killer Cell Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- PKCθ Signaling in T Lymphocytes
- Primary Immunodeficiency Signaling
- Reelin Signaling in Neurons
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Tissue Factor in Cancer
- SAPK/JNK Signaling
- Sperm Motility
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-small cell lung carcinoma
- epithelial neoplasia
- metastatic non-small cell lung cancer
- severe combined immunodeficiency
- obesity
- severe acute respiratory syndrome
- insulin-dependent diabetes mellitus
- cutaneous melanoma
- precursor B-cell acute lymphoblastic leukemia
role in cell
- expression in
- number
- survival
- production in
- phosphorylation in
- migration
- commitment
- differentiation
- binding in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- endosomal membrane fractions
- glutaminergic synapse
- organelle
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- Golgi apparatus component
- cell cortex
- Plasma Membrane
- vesicles
- centrosome
- membrane compartment
- intercellular junctions
- immunological synapses
- cytosol
- microdomains
- recycling endosomes
- endocytotic vesicle
- membrane rafts
- membrane processes
- perikaryon
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lck gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- T cell costimulation
- hemopoiesis
- cellular zinc ion homeostasis
- transmembrane receptor protein tyrosine kinase signaling pathway
- peptidyl-tyrosine autophosphorylation
- Fc-gamma receptor signaling pathway
- response to xenobiotic stimulus
- protein phosphorylation
- T cell differentiation
- positive regulation of T cell receptor signaling pathway
- positive regulation of T cell activation
- innate immune response
- positive regulation of heterotypic cell-cell adhesion
- leukocyte migration
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- release of sequestered calcium ion into cytosol
- positive regulation of intrinsic apoptotic signaling pathway
- platelet activation
- intracellular signal transduction
- T cell receptor signaling pathway
- B cell receptor signaling pathway
- regulation of lymphocyte activation
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- extracellular vesicular exosome
- membrane raft
- cytosol
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- T cell receptor binding
- CD4 receptor binding
- SH2 domain binding
- receptor binding
- CD8 receptor binding
- phosphotyrosine binding
- protein serine/threonine phosphatase activity
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- phospholipase binding
- phospholipase activator activity
- ATPase binding