HOXC5 Gene Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
HOXC5
Official Name
homeobox C5 [Source:HGNC Symbol;Acc:HGNC:5127]
Ensembl ID
ENSG00000172789
Bio databases IDs NCBI: 3222 Ensembl: ENSG00000172789
Aliases homeobox C5
Synonyms
CP11,homeo box C5,HOX3,Hox-3.4,HOX3D,Hox-6.2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • transcription regulator
  • protein binding
  • transcription factor activity
  • homeodomain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypoplasia
  • gout
  • adenoma formation
  • pituitary gland adenoma
  • head and neck neuroendocrine neoplasia
regulated by
  • metribolone
  • beta-estradiol
  • dihydrotestosterone
  • BCOR
  • tretinoin
  • KAT6A
  • birabresib
  • MIR3648
  • histone H2A
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cell junction
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the HOXC5 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • anterior/posterior pattern specification
  • embryonic skeletal system development
  • regulation of transcription from RNA polymerase II promoter

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • cell junction
  • chromatin
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • sequence-specific DNA binding transcription factor activity
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.