This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription regulator
protein binding
transcription factor activity
homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
Nucleus
cell junction
nucleoplasm
chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HOXC5 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
anterior/posterior pattern specification
embryonic skeletal system development
regulation of transcription from RNA polymerase II promoter
cellular COMPONENT
Where in the cell the gene product is active
nucleus
cell junction
chromatin
nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
sequence-specific DNA binding transcription factor activity
protein binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific DNA binding RNA polymerase II transcription factor activity
Gene-Specific Assays for Results You Can Trust
Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.