PPP3CB Gene Summary [Human]
Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPP3CB |
| Official Name | protein phosphatase 3 catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9315] |
| Ensembl ID | ENSG00000107758 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3 catalytic subunit beta, calcineurin A beta, protein phosphatase 2B, catalytic subunit, beta isoform |
| Synonyms | 1110063J16Rik, CALCINEURIN A1, Calcineurin A Beta, Calcineurin A β, CALNA2, CALNB, CNA2, Cnab, CnA beta, Cn A β, PP2Bbeta, protein phosphatase 3 catalytic subunit beta, Protein phosphatase 3 catalytic subunit beta isoform, protein phosphatase 3, catalytic subunit, beta isoform, protein phosphatase 3 catalytic subunit β, Protein phosphatase 3 catalytic subunit β isoform, protein phosphatase 3, catalytic subunit, β isoform |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP3CB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- autoinhibitory protein domain
- calmodulin binding
- catalytic domain
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- calmodulin binding domain
- calcium ion binding
- enzyme binding
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- Calcineurin-like phosphoesterase
- binding protein
- protein phosphatase 2B binding
- calcium-dependent protein serine/threonine phosphatase
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
- calcineurin B binding domain
Pathways
Biological processes and signaling networks where the PPP3CB gene in human plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- B Cell Receptor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperlipidemia
- obesity
- renal failure
- diabetes mellitus
- schizophrenia
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- precursor B-cell acute lymphoblastic leukemia
- COVID-19
- rheumatoid arthritis
role in cell
- differentiation
- proliferation
- apoptosis
- activation
- expression in
- extension
- quantity
- activation in
- accumulation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- synapse
- Z line
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP3CB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- T cell activation
- positive regulation of transcription from RNA polymerase II promoter
- learning
- protein phosphorylation
- memory
- T cell homeostasis
- regulation of insulin secretion
- heart development
- skeletal muscle fiber development
- positive regulation of transcription, DNA-dependent
- regulation of synaptic plasticity
- lymphangiogenesis
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- dephosphorylation
- positive regulation of protein localization to nucleus
- calcineurin-NFAT signaling cascade
- signal transduction
- regulation of synaptic vesicle endocytosis
- protein dephosphorylation
- T cell differentiation
- locomotion involved in locomotory behavior
- negative regulation of signaling
- axon extension
- T cell proliferation
- T cell mediated cytotoxicity
- negative regulation of T cell mediated cytotoxicity
- calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- Z disc
- T-tubule
- calcineurin complex
- protein serine/threonine phosphatase complex
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- calmodulin binding
- calmodulin-dependent protein phosphatase activity
- protein binding
- calcium ion binding
- protein dimerization activity
- myosin phosphatase activity
- enzyme binding
- protein phosphatase 2B binding