ZBTB16 Gene Summary [Human]
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB16 |
| Official Name | zinc finger and BTB domain containing 16 [Source:HGNC Symbol;Acc:HGNC:12930] |
| Ensembl ID | ENSG00000109906 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 16, promyelocytic leukaemia zinc finger |
| Synonyms | AI467657, KRUPPEL-LIKE ZNF, lu, LX, PLZF, promyelocytic leukaemia zinc finger, Zfp145, zinc finger and BTB domain containing 16, ZNF145 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- BTB_POZ
- G-protein-coupled receptor binding
- protein domain specific binding
- central domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- proline rich domain
- identical protein binding
- DNA binding
- C2H2-type zinc finger
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- protein homodimerization
- BTB/POZ domain
- zinc finger domain
- RD2 domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the ZBTB16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- Alzheimer disease
- epithelial cancer
- polycystic ovary syndrome
- pervasive developmental disorder
- ulcerative colitis
- asthma
- interstitial fibrosis
- hyperplasia
role in cell
- growth
- proliferation
- expression in
- apoptosis
- cell viability
- invasion
- cell cycle progression
- production in
- size
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular space
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
- phalangeal processes
- PML nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of cartilage development
- hemopoiesis
- negative regulation of cell proliferation
- anterior/posterior pattern specification
- positive regulation of fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- embryonic digit morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- mesonephros development
- apoptotic process
- forelimb morphogenesis
- protein localization to nucleus
- embryonic hindlimb morphogenesis
- negative regulation of myeloid cell differentiation
- embryonic pattern specification
- ossification involved in bone maturation
- positive regulation of ossification
- regulation of transcription from RNA polymerase II promoter
- male germ-line stem cell division
- central nervous system development
- positive regulation of apoptotic process
- myeloid cell differentiation
- positive regulation of chondrocyte differentiation
- positive regulation of NK T cell differentiation
- cartilage development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- transcriptional repressor complex
- nuclear speck
- cytosol
- macromolecular complex
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- type 2 angiotensin receptor binding
- DNA binding
- protein domain specific binding
- identical protein binding
- protein homodimerization activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription