H2-Oa Gene Summary [Mouse]
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and regulation of T cell differentiation. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in several structures, including central nervous system; cornea; genitourinary system; palatal shelf; and salivary gland primordium. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | H2-Oa |
| Official Name | histocompatibility 2, O region alpha locus [Source:MGI Symbol;Acc:MGI:95924] |
| Ensembl ID | ENSMUSG00000024334 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, O region alpha locus |
| Synonyms | H2-Oa, histocompatibility 2, O region alpha locus, histocompatibility 2, O region α locus, HLA-DNA, HLA-DOalpha, HLADZ, HLA-DZA, major histocompatibility complex, class II, DO alpha, major histocompatibility complex, class II, DO α, MHC-D0-alpha, MHC-D0-α, MHC DZ alpha, MHC DZ α, RT1 class II, locus DOa, RT1-DOa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Oa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- MHC class II receptor
- binding protein
- immunoglobulin domain
- Class II histocompatibility antigen, alpha domain
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the H2-Oa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic hepatitis B
- multiple sclerosis
- colon cancer
- insulin-dependent diabetes mellitus
- myasthenia gravis
- periodontitis
- Down syndrome
- androgenic alopecia
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
regulates
- MHC II (complex)
- peptide
- IgG1
role in cell
- activation
- differentiation
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2-Oa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of antigen processing and presentation of peptide antigen via MHC class II
- regulation of T cell differentiation
- positive regulation of T cell activation
- peptide antigen assembly with MHC class II protein complex
- adaptive immune response
- positive regulation of immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- late endosome membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- peptide antigen binding
- protein binding
- MHC class II receptor activity
- MHC class II protein complex binding