Marchf1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Located in bounding membrane of organelle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain; glossopharyngeal ganglion; and spinal cord. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Marchf1 |
| Official Name | membrane associated ring-CH-type finger 1 [Source:MGI Symbol;Acc:MGI:1920175] |
| Ensembl ID | ENSMUSG00000036469 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 1 |
| Synonyms | 2900024D24Rik, LOC100910061, MARCH1, MARCH-I, membrane associated ring-CH-type finger 1, RGD1305148, RNF171 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Marchf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC protein binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chickenpox
- herpes zoster
- neoplasia
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- insomnia
- multiple sclerosis
- hypertension
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- production in
- expression in
- binding
- activation
- function
- differentiation
- downregulation in
- quantity
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Marchf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- protein polyubiquitination
- antigen processing and presentation of peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- endoplasmic reticulum
- lysosomal membrane
- plasma membrane
- lysosome
- early endosome membrane
- endoplasmic reticulum membrane
- late endosome membrane
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- MHC protein binding