Serpina1d Gene Summary [Mouse]
Predicted to enable identical protein binding activity; protease binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Located in extracellular region. Is expressed in gut and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpina1d |
| Official Name | serine (or cysteine) peptidase inhibitor, clade A, member 1D [Source:MGI Symbol;Acc:MGI:891968] |
| Ensembl ID | ENSMUSG00000071177 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade A, member 1D |
| Synonyms | [A]1-PI, A1-PI, AAT, AAT2, AI118301, Alpha1 Antitrypsin, Alpha 1 Protease Inhibitor, alpha-1 protease inhibitor 3, alpha-1 protease inhibitor 5, alpha 1 PROTEINASE INHIBITOR, Alpha at1, D12Ucla2, Dom1, Dom2, Dom4, Dom5, DOM-7, Elafin, PI1, PI2, Pi3, PI4, PI5, Pi6, serine (or cysteine) peptidase inhibitor, clade A, member 1A, serine (or cysteine) peptidase inhibitor, clade A, member 1C, serine (or cysteine) peptidase inhibitor, clade A, member 1D, serine (or cysteine) peptidase inhibitor, clade A, member 1E, serine (or cysteine) preptidase inhibitor, clade A, member 1B, Serine protease inhibitor 1-2, SERPINA1, Serpina1b, Serpina1c, Serpina1d, Serpina1e, Skalp, Spi1-1, Spi1-2, Spi1-3, Spi1-4, Spi1-5, Spi1-6, Wap3, α 1 Protease Inhibitor, α-1 protease inhibitor 3, α-1 protease inhibitor 5, α 1 PROTEINASE INHIBITOR, α at1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpina1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- furin cleavage site
- identical protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serpina1d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pulmonary emphysema
- blistering
- hepatic steatosis
- infection by HIV
role in cell
- expression in
- phosphorylation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Golgi Apparatus
- Endoplasmic Reticulum