Lrp1 Gene Summary [Mouse]
Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and negative regulation of Wnt signaling pathway. Located in external side of plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp1 |
| Official Name | low density lipoprotein receptor-related protein 1 [Source:MGI Symbol;Acc:MGI:96828] |
| Ensembl ID | ENSMUSG00000040249 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 1 |
| Synonyms | A2MR, alpha-2-macroglobulin receptor, APOER, APR, b2b1554Clo, CD91, DDH3, IGFBP-3R, IGFBP3R1, KPA, LDL receptor related protein 1, LDL-RELATED 1, low density lipoprotein receptor-related protein 1, LRP, Lrp1 beta, Lrp1 β, TGFBR5, α-2-macroglobulin receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- variable heavy chain
- LRP cluster 2 domain
- clathrin binding
- NHL repeat unit of beta-propeller proteins
- NPXY motif
- endocytic domain
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- LDLa
- apolipoprotein receptor
- tail domain
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- coreceptor
- extracellular domain
- ligand binding repeat
- cargo receptor activity
- protein kinase binding
- signaling receptor activity
- protease binding
- alpha-2 macroglobulin receptor
- ectodomain
- calcium ion binding
- protein binding
- receptor binding
- Low-density lipoprotein receptor repeat class B
- EGF-like domain
- complement-type repeat
- endocytic signal motif
- binding protein
- LRP cluster 4 domain
- scavenger receptor
- transmembrane domain
- cytosolic tail domain
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
- EGF repeat
- LRP cluster 3 domain
Pathways
Biological processes and signaling networks where the Lrp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Inhibition of Matrix Metalloproteases
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic obstructive pulmonary disease
- asthma
- streptozotocin-induced diabetes
- dystonia
- aortic aneurysm
- migraines
- Alzheimer disease
- atherosclerosis
- androgenic alopecia
role in cell
- cell death
- disassembly
- expression in
- growth
- quantity
- apoptosis
- invasion by
- binding in
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- glutaminergic synapse
- proximal axon
- endocytic vesicle membrane
- axon component
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- postsynaptic region
- intracellular membranes
- cellular membrane
- endosomes
- lysosome
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- caveolae
- synaptic membrane
- basolateral membrane
- sinusoidal membrane
- nucleoli
- dendritic spines
- synaptic vesicles
- neurites
- early endosomes
- GLUT4 vesicles
- secretory granules
- clathrin-coated pits
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
- clathrin-coated vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lipid transport
- positive regulation of protein binding
- regulation of cholesterol transport
- positive regulation of endocytosis
- astrocyte activation involved in immune response
- lipoprotein transport
- regulation of phospholipase A2 activity
- beta-amyloid clearance
- retinoid metabolic process
- transcytosis
- regulation of extracellular matrix disassembly
- positive regulation of cholesterol efflux
- negative regulation of smooth muscle cell migration
- negative regulation of SMAD protein import into nucleus
- lysosomal transport
- positive regulation of beta-amyloid clearance
- apoptotic cell clearance
- enzyme linked receptor protein signaling pathway
- receptor-mediated endocytosis
- negative regulation of gene expression
- aorta morphogenesis
- regulation of actin cytoskeleton organization
- lipid metabolic process
- phagocytosis
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of Wnt receptor signaling pathway
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- receptor complex
- plasma membrane
- lysosomal membrane
- nucleus
- early endosome
- microtubule organizing center
- focal adhesion
- coated pit
- membrane
- basolateral plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- alpha-2 macroglobulin receptor activity
- apolipoprotein binding
- clathrin heavy chain binding
- cargo receptor activity
- signaling receptor activity
- low-density lipoprotein receptor activity
- scavenger receptor activity
- beta-amyloid binding
- RNA binding
- protein binding
- calcium ion binding
- heparan sulfate proteoglycan binding
- lipoprotein particle receptor binding
- apolipoprotein receptor activity