REXO5 Gene Summary [Human]
Predicted to enable exonuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | REXO5 |
| Official Name | RNA exonuclease 5 [Source:HGNC Symbol;Acc:HGNC:24661] |
| Ensembl ID | ENSG00000005189 |
| Bio databases IDs | |
| Aliases | RNA exonuclease 5 |
| Synonyms | 2610020H08Rik, AC0043816, AC004381.6, DKFZp434J0315, ENEF, Exnef, LOC81691, NEF-sp, RGD1305412, RNA exonuclease 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REXO5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- RNA recognition motif
- EXOIII
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REXO5 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- exonuclease activity